Pathway 6 is hydrolysis of the drug acyl-CoA back to the parent drug and may be catalyzed by acyl-CoA thioesterases that are present in many tissues, including liver, and whose main role is hydrolyzing fatty acid CoA thioesters of varying chain lengths (Hunt and Alexson, 2002). Rapid hyd...
free intramitochondrial AA is generated by the action of an acyl-coenzyme A (CoA) synthetase (ACSL4) and a mitochondrial acyl-CoA thioesterase (ACOT2). ACSL4 esterifies free AA to AA-CoA, which could be delivered to ACOT2 and, in turn, releases AA in the mitochondria upon hormone treat...
Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. Human fatty acid synthase (FAS) is uniquely expressed at high levels in many tumor types. Pharmacological inhibition of FAS therefore represents an importa... CW Pemble,LC Johnson,SJ Kridel,... - 《...
OPEN Citation: Cell Death and Disease (2017) 8, e2793; doi:10.1038/cddis.2017.202 Official journal of the Cell Death Differentiation Association www.nature.com/cddis Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway Seung Hee Jung1...
The kinetic parameters we measured for the palmitoyl CoA hydrolase activity of MBLAC2 are similar to those obtained for type I ACOTs. Members of type I ACOT enzymes are thioesterases that contain an α/β-hydrolase domain in the active site. The pioneering member and best characterized enzyme ...
Acyl-CoAthioesterases with different acyl-CoA chain length specificities andsubcellular localizationshave now been purified, cloned and characterized, which will be discussed below in relation to their possible roles in cellular metabolism and function. The activity has been referred to in the literature...