AcyltransferasesFatty Acid DesaturasesAmidohydrolasesFatty AcidsSubstrate SpecificityApparent kinetic constants ( K m and V max values) were determined for human liver acyl-CoA: glycine acyltransferase (glycine- N-acylase) towards isobutyryl-CoA, 2-methyl butyryl-CoA, isovaleryl-CoA, butyryl-CoA, ...
Acyl-CoA: GlycineN-Acyltransferases (GLYAT) GlycineN-acyltransferase (GLYAT) is a member of the Gcn5-relatedN-acetyltransferase (GNAT) superfamily ofN-acyltransferases, which uses anacyl-CoAand glycine as substrates (Vettinget al., 2005; Schachter and Taggart, 1954). The products of the reaction...
Acyl-CoA: lysophosphatidylcholine acyltransferases LPLATs: Acyl-CoA: lysophospholipids acyltransferases LPAATs: Acyl-CoA: lysophosphatidic acid acyltransferases LPEATs: Acyl-CoA: lysophosphatidylethanolamine acyltransferases VLC-PUFA: Very long-chain polyunsaturated fatty acids EPA; 20:5∆5,8,11,14...
The N-terminal regions of these mammalian acyltransferases have been shown to play a critical role in the formation of tetramers. Mutations of human DGAT1 devoid of the last 101 amino acid residues from the C-terminus (designated DGATsv) were shown to be catalytically inactive [21]. DGATsv,...
Two site-directed mutations within the wild-type 2-O-benzoyltransferase (tbt) cDNA, from Taxus cuspidata plants, yielded an encoded protein containing replacement amino acids at Q19P and N23K that map to a solvent-exposed loop region. The likely significant changes in the biophysical properties ...
Isolation and characterization of mitochondrial acyl-CoA:glycine N-acyltransferases from kidney. J. Biochem. Toxicol. 8: 63-69.Kelley M, Vessey DA. (1993). Isolation and characterization of mitochondrial acyl-CoA: Glycine N-acyltransferases from kidney. J BiochemToxicol 8:63-69....
Vessey, D. and Lau, E. (1998). Determination of the sequence of the arylacetyl acyl-CoA: amino acid N-acyltransferases from bovine liver mitochondria and its homology to the aralkyl acyl-CoA: amino acid N-acyltransferase. J. Biochem. Mol. Toxicol. 12, 275-279....
ACYL-CoA CHOLESTERYL ACYLTRANSFERASE INHIBITOR AND COMPOSITION COMPRISING THE SAME FOR HYPERLIPIDEMIAPROBLEM TO BE SOLVED: To provide a new substance having ACAT(acyl-CoA cholesteryl acyltransferases) inhibitory action.NISHIMURA KEIICHI西村 桂一MIYASE TOSHIO...
Mutant acyl-CoA:lysophosphatidylcholine acyltransferases ["LPCATs"] having the ability to convert acyl-CoA+1-acyl-sn-glycero-3-phosphocholine to CoA+1,2-diacyl-sn-glycero-3-phosphocholine (EC 2.3.1.23) are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such ...
Polynucleotide, mutant polypeptide, recombinant cell, recombinant construct, transformed cell, and transformed yarrowia cell are disclosed in the present invention. glycero-3-phosphocholine in coa + 1,2-diacyl-sn-glycero-3-phosphocholine (ec 2.3.1.23). Isolated nucleic acid fragments and recombinant ...