Acyl-CoA ligase from rat brain microsomes: an immunochemical study. Biochim. Biophys. Acta 963, 509-514.Singh I, Bhushan A, Relan NK, Hashimoto T: Acyl-CoA ligases from rat brain microsomes: an immunochemical study Biochim Biophys Acta 963: 509-514, 1988...
Acyl-CoA Synthetase (ACS) also known as Acyl-CoA ligase, is a ubiquitous enzyme that catalyzes the reaction of free fatty acids and Coenzyme A (CoA) to generate Fatty Acyl-CoAs through an ATP-dependent mechanism. The incorporation of this CoA moiety generates a thio-ester bond that effective...
17Citations 1Altmetric Metrics Abstract Acyl-coenzyme A (CoA) ligases catalyze the activation of carboxylic acids via a two-step reaction of adenylation followed by thioesterification. Here, we report the discovery of a non-adenylating acyl-CoA ligase PtmA2 and the functional separation of an ac...
Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis 来自 学术范 喜欢 0 阅读量: 56 作者:Sun, Xiao-Jie,Xu, Ge-Liang 摘要: BACKGROUND Recently, accumulating studies have found that ACSL4 dysregulation is related to a great number of malignant...
Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.doi:10.1074/jbc.M115.677195Streptomycesacyl-CoA ligasealkylmalonyl-CoAbiosynthesisenzyme catalysisnatural productpolyketide...
Moreover, RpfB can functionally replace the paradigm bacterial acyl-CoA ligase, Escherichia coli FadD, in the E. coli beta-oxidation pathway and deletion of RpfB from the Xcc genome results in a strain unable to utilize fatty acids as carbon sources. An essential RpfB function in the ...
Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis. Medical science monitor: international medical journal of experimental and clinical research 23, 4343–4350 (2017). Article Google Scholar Monaco, M. E. et al. Expression of Long-chain Fatty...
脂肪酸分解的限验因地乐速酶是脂酰辅酶A合成酶(激素敏感脂肪酶)。() 酮体不能在肝中氧化的主要原因是肝中缺乏A、HMG辅酶A合成酶B、HMG辅酶A裂解酶C、HMG辅酶A还原酶D、琥珀酰辅酶A... 脂肪酸氧化的限速酶是A、脂酰辅酶A合成酶B、肉毒碱脂酰转移酶ⅠC、脂酰辅酶A脱氢酶D、硫解酶E、Δ2烯酰水化酶请...
ACSL4, a member of the long-chain fatty-acid-coenzyme A ligase family, preferentially converts arachidonate and eicosapentaenoate intoacyl-CoAesters and thereby plays a key role in lipid metabolism. Knockout of ACSL4 lowers the levels of acyls-arachidonoyl (AA)- and adrenoyl (AdA)-containin...
When exogenous LCFAs are present (Fig. 1b), they are transported across the outer membrane by FadL and activated by the inner membrane-associated acyl-coenzyme A (CoA) ligase FadD7 to produce long-chain fatty acyl-CoAs (LCFA-CoAs). These LCFA-CoAs bind directly to FadR and induce a ...