Acyl-CoA dehydrogenases and acyl-CoA oxidases are two closely related FAD-containing enzyme families that are present in mitochondria and peroxisomes, respectively. They catalyze the dehydrogenation of acyl-CoA thioesters to the corresponding trans -2-enoyl-CoA. This review examines the structure of ...
Acyl-CoA dehydrogenases and acyl-CoA oxidases are two closely related FAD-containing enzyme families that are present in mitochondria and peroxisomes, respectively. They catalyze the dehydrogenation of acyl-CoA thioesters to the corresponding trans-2-enoyl-CoA. This review examines the structure of me...
7.03.3.2Acyl-CoA Dehydrogenases and Oxidases Acyl-CoA dehydrogenases (ACADs), flavoproteins found in the mitochondria, are involved in β-oxidation of fatty acids. Currently, there are five types of ACADs classified according to substrate specificity. Short-chain ACAD (SCAD), medium-ch...
Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase (ACX4) for β-oxidation of lipids. The short chain-specific oxidase has little resemblance to other peroxisomal acyl-CoA oxidases but has an ∼30% sequence identity to mitochondrial acyl-CoA dehydrogenases. Two biochemical ...
acyl‐CoA oxidase α,β‐dehydrogenationmechanismsAcyl-CoA dehydrogenases constitute a family of flavoproteins that catalyze the α,β-dehydrogenation of fatty acid acyl-CoA conjugates. While they differ widely in their specificity, they share the same basic chemical mechanism of α,β-dehydrogenation....
Acyl-CoA oxidase and the acyl-CoA dehydrogenases share many similarities in their interaction with CoA derivatives. For example, both enzymes stabilize the anionic radical on binding enoyl-CoA derivatives, both dehydrogenate 2-oxoheptadecyldethio-CoA but cannot utilize S-heptadecyl-CoA, both form ...
Ititrodiictioti Enzymic oxidation of acyl-CoA substrates to tratis-2,3enoyl-CoA thiolesters is a common reaction in the mitochondrial oxidation of fatty acids, branched-chain amino acids and lysine. These oxidations are catalysed by six flavoprotein dehydrogenases localized in the mitochondria1 matri...
Twitter Google Share on Facebook ac·yl·ad·e·nyl·ate (as'il-ă-den'il-āt), A compound in which an acyl group is combined with AMP by elimination of H2O from the carobxyl group and of the phosphate residue of AMP, usually in the initial form of ATP; inorganic pyrophosphate is...
Acyl-CoA dehydrogenases constitute a family of flavoproteins that catalyze the alpha,beta-dehydrogenation of fatty acid acyl-CoA conjugates. While they dif... S Ghisla,C Thorpe - 《Eur J Biochem》 被引量: 293发表: 2004年 Detection of peroxisomal fatty acyl-CoA oxidase activity Fatty acyl-CoA...
10, 1983 Printedin U.S.A. On the Biologic Origin of C6-Clo-Dicarboxylicand C6-Clo-a-1-HydroxyMonocarboxylic Acids in Human and Rat with Acyl-CoA Dehydrogenation Deficiencies: in Vitro Studies on the u-and a-1-Oxidation of Medium-Chain (C6-CI2)Fatty Acids in Human and Rat Liver N. ...