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ACVR1 and its signalling were initially studied as a type I BMP receptor. Following the discovery of ACVR1 as the gene responsible for FOP, prior knowledge of ACVR1 was combined with new findings regarding its function and regulation in order to advance towards a potential treatment for this...
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While Bone Morphogenetic Protein (BMP) signaling fine-tunes the behaviors of endothelium in health and disease, how BMP signaling influences the proliferation of endothelium and therefore, modulates angiogenesis remains largely unknown. Here, we evaluated the role of Activin A Type I Receptor (ACVR1/...
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