The toxicity of NAC varies depending on the route of administration. The LD50 values for oral administration and an intraperitoneal injection (IP) of NAC in rats are 6000 mg/kg and 1205 mg/kg, respectively [20,21]. This result indicates the substantially higher acute toxicity of NAC by IP ...
N-acetyl cysteine (NAC) is a versatile drug used in various conditions, but the limitations and toxicities are not clear. The acute toxicity and toxicological mechanisms of an intraperitoneal injection of NAC in normal mice were deciphered. The LD50 for male and female BALB/cByJNarl mice were...