Definition Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) characterized by the expansion of leukemic cells blocked at the promyelocytic stage of the myelopoiesis. According to the French-American-British (FAB) classification of acute leukemia, APL corresponds ...
内容提示: 【疾病名】急性早幼粒细胞白血病 【英文名】acute promyelocytic leukemia 【别名】急性前髓细胞性白血病 急性早幼粒细胞性白血病 【ICD 号】C92.4 【病因和发病机制研究的进展】 1.病因研究进展 2.发病机制研究进展 (1)APL 患者细胞遗传学异常 急性早幼粒细胞白血病(APL)患者中 90%以上都具有特征性...
Acute promyelocytic leukemia (APL) is a unique subtype of the acute leukemias. It has distinct cytogenetics, clinical features, and biologic characteristics.
Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However, this progress has not yielded equivalent benefit in developing countries. The International Consortium on Acute Promyelocytic Leukemia (IC-APL...
The peripheral blood film is suspicious for acute promyelocytic leukemia (APL). Numerous abnormal promyelocytes are present with variable nuclear size and shape; and basophilic cytoplasm with granules that vary in number. Auer rods (often multiple) are visible in roughly 1/3 of the promyelocyte...
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In acute promyelocytic leukemia (APL), TRAIL was used to be token as a crucial molecule that was up-regulated by retinoic acid and induced the blast cell to differentiation and apoptosis. However, our findings indicated that AP1060 cell, an APL cell line, produced a high level of TRAIL, ...
We have studied in-vitro growth of leukemic progenitor cells (L-CFU) in ten patients with acute promyelocytic leukemia (APL). All patients showed consistently an extraordinarily high incidence of cluster formation under the stimulation of human placental conditioned medium (HPCM) and/or phytohemaggluti...
All-trans retinoic acid therapy for newly diagnosed acute promyelocytic leukemia: comparison with intensive chemotherapy Recent reviews on acute promyelocytic leukemia (APL) treatment have focused on comparing therapeutic approaches, including all- trans retinoic acid (ATRA)... N.,Asou,Koichi,... - 《...
Between April 2004 and December 2010, we conducted a prospective randomized controlled study comparing tamibarotene with all-trans retinoic acid (ATRA) in the maintenance therapy of newly diagnosed acute promyelocytic leukemia (APL), and here report the final results of this study with a median fol...