Mapping of a subset of differentially expressed proteins in pFF+ versus pFF- samples on the acute phase response signaling canonical pathway.Valeria SeverinoLivia MalorniAnna Emilia CicatielloVittoria D’EspositoSalvatore LongobardiNicola Colacurci
The acute phase response (APR) classically refers to the rapid reprogramming of gene expression and metabolism in response to inflammatory cytokine signaling. As components of the innate immune system, hepatocyte-derived acute phase proteins (APPs) play a central role in restoring tissue homeostasis. ...
We applied this approach to determine temporal profiles of protein secretion in the hepatocyte model cell lines HepG2 and HepaRG after stimulation of the acute-phase response (APR) by the cytokines IL1b and IL6. While the popular hepatocarcinoma cell line HepG2 showed an incomplete APR, ...
Cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) are involved in acute phase response (APR). C-reactive protein (CRP), the prototype acute phase protein, may represent an important component in the pathogenesis of arteriosclerosis and may also be a target for drug development. In...
The cytokines interleukin 1β and 6 (IL-1β, IL-6) mediate the acute phase response (APR). In liver, they regulate the secretion of acute phase proteins. Using RNA-seq in primary hepatocytes, we show that these cytokines regulate transcription in a bifur
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Prepercutaneous coronary intervention zalunfiban dose–response relationship to target vessel blood flow at initial angiogram in ST-elevation myocardial infarction—a post hoc analysis of the CEL-02 phase IIa study. Am. Heart J. 262, 75–82 (2023). Article CAS PubMed PubMed Central Google ...
Acute promyelocytic leukemia (APL) is designated M3 in the French-American-British (FAB) classification. Because of its unique clinical features and unique response to certain differentiation-inducing agents, and because of our advanced understanding of
The Phase 3 program will consist of two randomized, double-blind, placebo-controlled studies evaluating the efficacy and safety of VX-548 (100 mg first dose, followed by 50 mg every 12 hours) for acute pain after bunionectomy or abdominoplasty. The primary endpoint in both studies ...
Inflammatory response and course in acute pancreatitis The acute phase response during the course of AP is the net response of the pro-inflammatory and simultaneously occurring anti-inflammatory response. During the initial phase this may frequently result in a hyperinflammatory state, the development ...