Type of hematological malignancy was determined using ICD-10 codes and was first classified in 11 categories: acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), unknown type of acute leukemia, chronic lymphoid leukemia (CLL), multiple myeloma (MM), non-Hodgkin’s lymphoma (NHL), Hodg...
We identified patients with acute leukemia (myeloid and lymphoid) and PEM using appropriate ICD-10 diagnostic codes. We stratified patients with acute leukemia based on the presence or absence of PEM. A survey multivariable logistic and linear regression analysis was used to calculate adjusted odds ...
Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes ...
Keywords: acute myeloid leukemia; tumor immunological microenvironment; immunotherapy; immune checkpoint blockade; bispecific antibodies 1. Introduction Acute myeloid leukemia (AML) is characterized by bone marrow (BM) and tissue infiltration with proliferative, clonal, abnormally differentiated cells of ...