Hodge, C. Chambers, et al., Acute lung transplant rejection is associated with localized increase in T-cell IFN-α and TNF-α proinflammatory cytokines in the airways, Transplantation 84 (2007) 1452-1458.Hodge G, Hodge S, Chambers D, Reynolds PN, Holmes M. Acute lung transplant rejection ...
Lung Transplant, Acute RejectionLung Transplant, Acute RejectionAcute allograft rejection is defined histologically as a cell-mediated process characterized by perivascular and interstitial mononuclear cell infiltrates composed of T lymphocytes. Antibody-mediated...Pulmonary...
Despite advances in immunosuppression over the past 25 years, acute cellular rejection remains a common complication early after lung transplantation. Although acute cellular rejection has often not resulted in clinical signs or symptoms of allograft dysfunction, it has been widely recognized as a strong...
Lung transplantation is an established treatment of well-selected patients with end-stage respiratory diseases. However, lung transplant recipients have the highest rates of acute and chronic rejection among transplanted solid organs. Owing to ongoing alloimmune recognition and associated immune-driven airwa...
Exhaled nitric oxide in human lung transplantation: A noninvasive marker of acute rejection. Am J Respir Crit Care Med 1998;157: 1822-8.Exhaled nitric oxide in human lung transplantation. A noninvasive marker of acute rejection. Silkoff P E,Caramori M,Tremblay L,McClean P,Chaparro C,Kesten...
Acute (Cellular) Rejection The term acute rejection without a qualifier is used to describe acute cellular rejection. This is a cell-mediated process, in contrast to the antibody-mediated process of antibody-mediated (humoral) rejection. Most lung transplant recipients experience episodes of acute rej...
None of the lung transplant recipients who had COVID-19–associated ARDS demonstrated antibody-mediated rejection compared with 12.5% in those without COVID-19. At follow-up, all 30 lung transplant recipients who had COVID-19–associated ARDS were alive (median follow-up, 351 days [IQR, 176...
Accurate and non-invasive monitoring of allograft posttransplant is essential for early detection of acute cellular rejection and determines the long-term survival of the graft. Clinically, tissue biopsy is the most effective approach for diagnosing transplant rejection. Nonetheless, the procedure is inva...
Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society At follow-up, five patients were biopsied because of an increased serum creatinine (12.2%): two had an acute cellular rejection episode (Banf...
Among these examples, granulomatosis with polyangiitis, Goodpasture’s syndrome, acute interstitial lung diseases (ILD) associated with polymyositis, rheumatoid arthritis (RA), or other classical autoimmune diseases, and lung transplant rejection due to alloantibodies, also have very high rates of ...