with an uncertain impact on the outcome.4,5 The authors of the Australian study mention the paucity of previous literature about stage-specific distribution and survival in pediatric leukemias.1 Contemporary management of leukemia utilizes frontline stratification into "risk groups" rather than "stages....
Acute myeloid leukemiais a heterogeneous clonal disorder marked by rapid proliferation of myeloid-lineage cells arrested at varying stages of maturation [2]. The acquisition of pre-leukemic mutations in normalhematopoietic stem cellsresults in the competitive advantage of certain clones with resultant matu...
A structured population model of clonal selection in acute leukemias with multiple maturation stagesAcute leukemiaClonal selectionContinuously structured population modelsIntegro-differential equationsAsymptotic analysisRecent progress in genetic techniques has shed light on the complex co-evolution of malignant ...
Combination chemotherapy regimens have made long-term leukemia-free survival a reality in many children with acute lymphoblastic leukemia. Now rehabilitation is as much a part of pediatric oncology nursing as the exquisitely sensitive care required in the acute stages of the disease. 年份: 1975 收藏...
The erythroid/myeloid subtype of acute erythroid leukemia (acute erythroleukemia [AEL]) is a malignant myeloid proliferation characterized by impaired maturation of the myeloid series, with excess myeloblasts occurring in a background of expanded maturing erythropoiesis. ...
Analysis of leukemic cell phenotypes using cell surface antigens and various enzymes indicates that acute lymphoblastic leukemia (ALL) is a biologically heterogeneous disease consisting of four major subclasses with additional subsets existing within these subclasses. These different types of ALL appear to...
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per year in the United States alone. The hallmark of ALL is chromosomal abnormalities and genetic alterations involved in differen
Acute Myeloid Leukemia Background Acute myeloid leukemia (AML) is a heterogeneous group of disorders defined by the proliferation of immature hematopoietic elements. The prototypical disease is characterized by an expansion of immature myeloid cells (myeloblasts) to comprise 20% or greater of the bon...
The aim of this study was to evaluate the possible contribution VCS could make in a hematological laboratory for the diagnosis of acute myeloid leukemia (AML). MATERIALS AND METHODS. Peripheral blood samples from 42 AML patients and 58 normal donors were analyzed by flow cytometry with the VCS....
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with an incidence that increases with age, and a generally poor prognosis. The disease is clinically and genetically heterogeneous, and recent advances have improved our un