Between 2004 and 2017, a total of 1123 adult patients (median age 65 years; 61% males) with newly diagnosed acute myeloid leukemia (AML), not including acute promyelocytic leukemia, were seen at the Mayo Clinic. Treatment included intensive (=766) or lower intensity (=144) chemotherapy or ...
Between 2004 and 2017, a total of 1123 adult patients (median age 65 years; 61% males) with newly diagnosed acute myeloid leukemia (AML), not including acute promyelocytic leukemia, were seen at the Mayo Clinic. Treatment included intensive (n = 766) or lower intensity (n = 144)...
2) an antecedent myelodysplastic syndrome is common in acute leukemia with inv(3) or related abnormalities; 3) affected patients have a poor survival and are resistant to conventional chemotherapy; and 4) abnormal megakaryocytopoiesis in acute leukemia may also be associated with pericentric inversion...
As we delve into the intricate world of venetoclax combination therapy in relapsed or refractory acute myeloid leukemia (AML), our exploration not only aims to contribute to the current body of knowledge but also strives to inform future research directions, clinical decision-making, and the ongoing...
et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat. Genet. 51, 151–162 (2019). Article CAS PubMed Google Scholar McKeown, M. R. et al. Superenhancer analysis defines novel epigenomic subtypes of non-APL AML, including an RARα dependency targetable by SY-...
(median age 65 years; 61% males) with newly diagnosed acutemyeloid leukemia (AML), not including acute promyelocytic leukemia, were seen at the Mayo Clinic. Treatmentincluded intensive (n= 766) or lower intensity (n =144) chemotherapy or supportive care (n = 213), with respectivemedian ...
Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia. Ann Hematol 2005; 84: 368–375. Article Google Scholar Salipante SJ, Scroggins SM, Hampel HL, Turner EH, Pritchard CC . Microsatellite instability detection by next generation sequencing. Clin Chem ...
The Cancer and Leukemia Group B (CALGB) undertook the present study in 1974 based on this concept and the pilot findings. During the period when this study was being planned, two methods for administration of ara-C were in common use: intravenous (i.v.) infusion continuously for several ...
By using the combination of 伪-naphthyl butyrate esterase and chloroacetate esterase for cytochemical detection of monocytes and granulocytes, respectively, we examined and identified five adult patients with acute myeloid leukemia whose... CY Li,RL Phyliky,LT Yam - 《Mayo Clinic Proceedings Mayo Clin...
In another retrospective report from the Mayo Clinic, superior CR rate (93% VS. 64%, P = 0.01) was observed among patients with de novo APL treated with ATO and ATRA (n = 53) compared to t-APL (n = 11). However, no leukemia resistance was observed in either group and the low ...