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Current treatment options for non-responding patients are limited to enrollment into clinical trials or provision of supportive care. Strategies to develop combinatorial treatments to overcome acquired drug resistance and tumor heterogeneity have been effective across various cancer types11. In MDS and AML...
Combination therapy with Resveratrol and Celastrol using folic acid-functionalized Exosomes enhances the therapeutic efficacy of Sepsis, Advanced healthcare materials, 12 (2023) e2301325. Bhowmick T, Berk E, Cui X, MuzykantovS Muro VR. Effect of flow on endothelial endocytosis of nanocarriers targeted...
FITC-Esbp-BSANPs can target the lungs in an established ALI mouse model, and the nanoparticles are distributed in vivo.(A)TEM image;(B)UV images of the hydrolysate of Fitc, Fitc-labeled Esbp, DXM-loaded BSANP hydrolysate, and DXM-loaded Fitc-Esbp-BSANP hydrolysate from 200 to 600 nm....
We propose utilizing the terms daily fluid balance, cumulative fluid balance, and percent cumulative fluid balance to describe the fluid status objectively in sick children for the purpose of clinical care and research (Table 1). The two methodologies commonly utilized in the literature to describe ...
Laboratories, West Grove, PA, USA; 1:5,000) in TBST, and immunoreactivity was visualized with the Luminate Forte Western HRP substrate (Millipore) according to the manufacturer’s protocol, and chemiluminescence signals were digitized using an Amersham Imager 600 (GE Healthcare, Little Chalfont, ...
However, care should be taken when considering frequency of testing, messaging around the role and interpretation of asymptomatic rapid tests, integration of data storage and access, and the challenges faced when scaling up surveillance to large populations. The role out of a new testing strategy ...
Overall, targeting the ZMYND8 reader cassette may be a viable and novel potential therapeutic approach to selectively suppress the essential IRF8-MEF2D and MYC transcriptional programs in AML. Limitations of study While our in vitro data comparing the effect of loss of ZMYND8 in IRF8hi AML ...
B cell leukaemia is one of the most frequent malignancies in the paediatric population, but also affects a significant proportion of adults in developed co
deeper understanding of gene expression programs driven by HIFs and their roles in cancer biology is necessary for better design and use of HIF-based interventions. Although both HIF1A and HIF2A are stabilized upon exposure to hypoxia and regulate overlapping sets of target genes, evidence suggests...