et al. Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways. Plos one 9(12), e113860 (2014). Article PubMed PubMed Central ADS Google Scholar Amathieu, R. et al. Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive...
Nonalcoholic fatty liver disease (NAFLD) in the Veterans Administration population: development and validation of an algorithm for NAFLD using automated data. Aliment Pharmacol Ther. 2014;40(8):949-954. doi:10.1111/apt.12923 PubMedGoogle ScholarCrossref 12. Aithal GP, Watkins PB...
Precipitating events Intrahepatic (alcoholic hepatitis), extrahepatic (infection, gastrointestinal haemorrhage), or both Intrahepatic, extrahepatic, or both Intrahepatic (HBV reactivation), extrahepatic (bacterial infection) or both Intrahepatic Definition of organ system failures 6 organ systems are considered ...
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participan...
Alcohol-related: fatty liver disease, acute alcoholic hepatitis, or alcoholic cirrhosis Drugs and toxins Dose-dependent, e.g. acetaminophen (paracetamol) Non-dose-dependent, e.g., idiosyncratic drug reaction most commonly related to antibiotics and anticonvulsants but also statins, NSAIDs, herbal/nut...
alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in ...
Serum 1H-NMR Metabolomic Fingerprints of Acute-On-Chronic Liver Failure in Intensive Care Unit Patients with Alcoholic Cirrhosis Introduction: Acute-on-chronic liver failure is characterized by acute deterioration of liver function in patients with compensated or decompensated, but s... Roland,Amathieu...
Alcoholic hepatitis (AH) is an acute form of ALD typified by jaundice and liver failure [4]. AH has a high short-term mortality, which has not improved over time despite trials of multiple agents [5]. The presence of obesity increases the risk of clinically significant liver disease and ...
It was also suggested that liver failure due to viral hepatitis might have a poorer prognosis. However, in type A and B ACLF in our study, the prognosis of HBV-ACLF was not significantly worse than that of ACLF with alcoholic liver disease. The prognostic impact of different etiologies, ...
Alcohol-related liver disease was the main etiology (57.4%, alcoholic hepatitis), followed by HBV reactivation (21.2%). The 60-day survival was evaluated, as well as the differences regarding the score on the Child-Turcotte-Pugh (CTP) scale, Model for End-Stage Liver Disease (MELD), and ...