In view of building a workable molecular model of tetraliganded zinc at the active site of carbonic anhydrase, an ab initioSCF study using pseudopotentials is performed on Zn2+(OH2)n from n = 2 to 6, Zn2+(NH3)n1 (OH2) for n = 2 and 4, Zn2+(NH3)2 (imidazole) (OH2), and...
arbonic anhydrase 1 Ab initio MO study on the catalytic mechanism in the active site of carbonic anhydrase 1Ab initio MO study on the catalytic mechanism in the active site of carbonic anhydrase 1Ab initio molecular orbital methodActive site model of carbonic anhydrase...
The carbonic anhydrases (CAs, EC 4.2.1.1) catalyse a simple but physiologically crucial reversible reaction, the carbon dioxide hydration with the production of bicarbonate and protons. In the last years, and especially, to the rapid emergence of the bacterial antibiotic resistance that is occurring...
We have prepared a site-specific mutant of human carbonic anhydrase (HCA) II with histidine residues at positions 7 and 64 in the active site cavity. Using a different isozyme, we have placed histidine residues in HCA III at positions 64 and 67 and in another mutant at positions 64 and 7...
carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site. J Med Chem 2015;58: 1494-501.Tanpure, R.P.; Ren, B.; Peat, T.S.; Bornaghi, L.F.; ... R Tanpure,B Ren,T Peat,... - 《Journal of Medicin...
The structure of the active site in carbonic anhydrases is well known from a number of crystal structures. Struktura aktivnog mjesta u ugljik anhidrazama je dobro poznata iz broja kristalnih struktura. WikiMatrix A heterogeneous catalyst has active sites, which are the atoms or crystal fa...
Human carbonic anhydrase II (hCAII) plays an important role as a rigid model protein in medicinal chemistry. Under physiological conditions in solution, NMR spectroscopy combined with molecular dynamics simulations demonstrates that the active site shows pronounced open/close conformational exchange, ...
Using the example of carbonic anhydrase, describe how this site can interact with a substance to make a product. Why is the active site of an enzyme important? What is the difference between an enzyme and a substrate? What is the difference between a co-enzyme and a substrate? G...
Carbonic anhydrase: an insight into the zinc binding site and into the active cavity through metal substitution. Structure and Bonding (Berlin) 1981; 48 ... Bertini,Ivano 被引量: 0发表: 1982年 Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of hu...
Environments previously thought to be uninhabitable offer a tremendous wealth of unexplored microorganisms and enzymes. In this paper, we present the discovery and characterization of a novel γ-carbonic anhydrase (γ-CA) from the polyextreme Red Sea brine pool Discovery Deep (2141 m depth, 44.8 ...