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3Hokkaido University Hospital Gastroenterological Medicine, Sapporo, Hokkaido 060-8648, Japan. Correspondence and requests for materials should be addressed toT.H. (email: hattori_tomohisa@mail.tsumura.co.jp) Scientific Reports | 6:27516 | DOI: 10.1038/srep27516 1 www.nature.com/scientificreports/ ...