Furthermore, TIAM1 overexpression rescued most of the ECM adhesion defect phenotype that characterizes RIN2-silenced ECs (Supplementary information, Figure S11B). Thus, the Rac1 GEF TIAM1 emerges as a key transducer of the pro-adhesive signaling elicited by the R-Ras/RIN2/Rab5 complex. ...