Christian Schwager2, Birgit Höft3, Irene Esposito4,* & Karin Müller-Decker1,* Mutational activation of K-Ras is an initiating event of pancreatic ductal adenocarcinomas (PDAC) that may develop either from pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplas...
cancer/ transformed cells (n ≥ 3, where n is the number of independent experiments), IP = immunoprecipitation; IB = immunoblotting. aMminnuudctotacmanFttLpsiIoaoPrnifLsFioenAxnpDttroheDesthsaiDeonnwEd.DiclAdFdsLtyomIPpmeeLnat(towiiontinn)oevFdfeAsFiDtnAigDFDaitagDen...
BMC Plant Biology volume 10, Article number: 182 (2010) Cite this article 10k Accesses 122 Citations Metrics details Abstract Background The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine an...
phosphoryla— tion.TheaboveeffectsofCSEwereconcentration-dependent.TheexpressionofFAKandthede— greeofitsphosphorylationwaspositivelycorrelatedtotheincreasednumberofepithelialcellsinG1 phase,andnegativelytothenumberofepithelialcellsinSandG2phases.Itwasconcludedthatthe mechanismbywhichCSEcouldinhibittheproliferationof...
210009 China Abstract ThesystematicresearchWascarriedoutforcoalganguecalcinedatdifferenttemperatures WhichWasusedascement mixture soastofindtheoptimumtemperatureforactivationofcoalgangue.TheWayofcalciningcoalgangueWithcalcium Waschosentoraisetheactivityofcoalgangue.Inordertomakeclearabouttheactivationprocessofcoalgangue ...
Therefore, it would be of interest to study the subcellular localisation and potential aggregation of two new β-glucosidases closely related to RGD (and to lesser extend to SGD) that have been implicated in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha [45] and for which...
However, besides a few examples, the regulation of SiO2 NP-responsive proteins and their functions in SiO2 NP response remain largely unknown. In this study, we demonstrated that SiO2 NP induced the expression of follistatin (FST), a stress responsive gene, in mouse lung tissue as well as in...
Once a large number of coarse grained intermediates were generated, eight were finally selected which differed from each other by at least >2 Å RMSD (of the alpha carbons of the backbone trace). The side chains of these intermediates were modeled using the PD2 ca2main server (http:...
Interestingly, we observed a significant number of radial chromosomes in the passage 7 Mre11RK/RK MEFs but not in the wild-type MEFs (Figure 3A, right panel and Table 1). These findings demonstrate the requirement for the MRE11 GAR motif for the main- tenance of chromosomal stability. In ...
2.3. Raising [AITC] Increases the Fraction of TGNs That Exhibit an Increase in [Ca2+]i Another factor pertinent to the amount of CGRP release elicited is the number of cells activated by each [AITC]. To evaluate this, after exposure to AITC as detailed in Figure 2, TGNs were subsequently...