Antigen binding by B cell receptors (BCR) on cognate B cells elicits a response that eventually leads to production of antibodies. However, it is unclear what the distribution of BCRs is on the naïve B cell and how antigen binding triggers the first step in BCR signaling. Using DNA-PAIN...
However, failure of periphery immune tolerance could trigger excessive activation of B cell and induced autoimmunity. Previous studies have confirmed this. For example, immune compromised mice were engrafted with human hematopoietic stem cells carrying FcγRIIb-232Ile or FcγRIIb-232 Thr alleles [28...
B CELL ACTIVATION | Activation of B-1 Cells; B CELL ACTIVATION | B Cell–Associated Surface Molecules and B Cell Responses; B CELL ACTIVATION | Cytokine Regulation of B Cell Activation and Differentiation; B CELL ACTIVATION | Cytokine-Producing Effector B Cells; B CELL ACTIVATION | Extrafollicula...
Immune system - T Cells, B Cells, Activation: In its lifetime a lymphocyte may or may not come into contact with the antigen it is capable of recognizing, but if it does it can be activated to multiply into a large number of identical cells, called a clo
17,18. However, at present, little is known about the regulation of DCs or macrophages on B-cell activation and functions in human tumoursin situ. Thus, evaluating the FcγRII expression and the functional data on B cells in the presence of DCs or macrophages in cancer environments are ...
BCG activated OKT4+ cells mediate suppression of antigen induced T cell prolifera... Peripheral blood mononuclear cells (PBMC), obtained from BCG vaccinated healthy donors, were induced to proliferation by BCG for five days in vitro. When r... AS Mustafa,T Godal - 《Clinical & Experimental ...
Optimal B-cell activation requires a DNA motif in which an unmethylated CpG dinucleotide is flanked by two 5' purines and two 3' pyrimidines. Oligodeoxynucleotides containing this CpG motif induce more than 95% of all spleen B cells to enter the cell cycle. These data suggest a possible ...
Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr. Mice homozygous for lpr and gld develop profound lymphadenopathy characterized by the accumulation of two functionally anergic T cell subsets, a predominant B220+CD4-CD8- double negative (DN) population and...
IL-2-dependent activated cells undergo apoptotic death when IL-2 is withdrawn either in vitro or after in vivo cell transfer. To attempt to sustain their s... K Liu,SA Rosenberg - 《Journal of Immunology》 被引量: 245发表: 2001年 Increased calpain correlates with Th1 cytokine profile in ...
Activation of T-cell proliferation specifically in a tumor is crucial for reducing the autoimmune side effects of antitumor immunotherapy. Herein, we developed a pH-driven interlocked DNA nano-spring (iDNS) to stimulate T-cell activation in vivo in response to the low pH value in a tumor micro...