Antigen binding by B cell receptors (BCR) on cognate B cells elicits a response that eventually leads to production of antibodies. However, it is unclear what the distribution of BCRs is on the naïve B cell and how antigen binding triggers the first step in BCR signaling. Using DNA-PAIN...
B CELL ACTIVATION | Activation of B-1 Cells; B CELL ACTIVATION | B Cell–Associated Surface Molecules and B Cell Responses; B CELL ACTIVATION | Cytokine Regulation of B Cell Activation and Differentiation; B CELL ACTIVATION | Cytokine-Producing Effector B Cells; B CELL ACTIVATION | Extrafollicula...
However, failure of periphery immune tolerance could trigger excessive activation of B cell and induced autoimmunity. Previous studies have confirmed this. For example, immune compromised mice were engrafted with human hematopoietic stem cells carrying FcγRIIb-232Ile or FcγRIIb-232 Thr alleles [28...
Naïve cells can still differentiate into another type of T or B effector cell. Many effector cells are considered “terminally differentiated,” meaning they will never change into another cell type and have reached the end of their differentiation and maturation process. They are fully activated ...
17,18. However, at present, little is known about the regulation of DCs or macrophages on B-cell activation and functions in human tumoursin situ. Thus, evaluating the FcγRII expression and the functional data on B cells in the presence of DCs or macrophages in cancer environments are ...
Optimal B-cell activation requires a DNA motif in which an unmethylated CpG dinucleotide is flanked by two 5' purines and two 3' pyrimidines. Oligodeoxynucleotides containing this CpG motif induce more than 95% of all spleen B cells to enter the cell cycle. These data suggest a possible ...
B. DelanyN. E. KaminskiSpringer-VerlagArchives of ToxicologyKoh WS, Yang KH, Jeong TC, Delany B, Kaminski NE. 2-Acetylamino- fluorene inhibits the activation of immune responses by blocking cell cycle progression at G1 phase. Arch Toxicol 1995;69:350 - 6....
LK Mostafa,DB Jones,DH Wright - 《Journal of Pathology》 被引量: 82发表: 1980年 HIV-1 infection of microvascular endothelial cells facilitates growth of AIDS associated B cell lymphomas: 125 AIDS patients have a high incidence of aggressive B cell nonHodgkin's lymphomas (AIDS-NHL) that involv...
(A) C6 cells were exposed to antimony at different concentrations (0, 0.01, 0.05, 0.1, 1, 5, 10, 20, 40 μmol/L) for 24 h, and optical density A value of CCK8 regents was used to assess cell proliferation and cytotoxicity. (B) C6 cells were exposed to the indicated antimony ...
The B cell antigen receptor (BCR) employs enzymatically inactive adaptor proteins to facilitate activation of intracellular signaling pathways. In animal model systems, adaptor proteins of the growth factor receptor-bound 2 (Grb2) family have been shown to serve critical functions in lymphocytes. Howev...