e, Distributions of droplet size for eGFP-AR-ΔNLS and mutants in PC3 cells as a function of tDHT. Each dot corresponds to the mean droplet size in a single cell (n > 20 cells), boxes shown the mean and the quartiles of all cells and P values were calculated using a Mann–...
determining an anticipated total benefit (Nges) when activating the function depending on the reliability of the signal or the sub-quantity of the signal and activating/deactivating the function only if the total benefit to be anticipated is greater than a defined threshold value, especially greater...
To enable gain-of-function and loss-of-function arrayed CRISPR screens, we generated genome-wide activation (‘T.gonfio’, meaning swelling up) and deletion (‘T.spiezzo’, meaning breaking in two) arrayed libraries for human protein-coding genes using ALPA cloning (Fig. 1e). We used the...
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Thus, LFA-1/ICAM-1 interaction lowers the threshold for B cell activation by promoting B cell adhesion and synapse formation. 展开 关键词: LFA-1/ICAM-1 Interaction Lowers the Threshold of B Cell Activation by Facilitating B Cell Adhesion and Synapse Formation, Artículo ...
R. S. Lenk1. Borough Polytechnic, London S.E.I., England ;Steinkopff-VerlagRheologica ActaLenk, R. S. : 1965 , ‘ Activation Energy of Viscoelastic Flow of Emulsion Inks as a Function of Shear Rate ’, Rheol. Acta 4 , 282 ....
Two-sample t-tests were then performed to compare activation across groups (e.g., football vs. cross country; football vs. SES-matched non-athlete). For the contrasts examined, we applied a Monte Carlo simulation of the brain volume to establish an appropriate voxel contiguity threshold. The ...
If Windows Vista SP1 and Windows Server 2008 systems are not activated within the Initial Grace period or an Out of Tolerance Grace period, persistent notifications will alert users of the need to activate. While in the notification condition, the system will function normally, with these ...
Treg-specific Vps33B depletion in mice leads to defective Treg suppressive function, T cell hyper-activation, and boosted antitumor immunity. Mechanistically, Vps33B depletion leads to accumulation of late endosome/lysosome and LYNUS, resulting in elevated mTORC1 activity, accompanied by increased ...
The unfolded protein response (UPR) induced during ER stress can be divided into three signaling pathways, where the PERK pathway activated by the transcription factor ATF4 initiates the mildest response, restoring ER function by attenuating non-essential protein synthesis59. We reasoned that ATF4 exp...