An increase in the expression of genes involved in ubiquitin-mediated proteolysis is observed during many forms of muscle wasting. Hence we analyzed the effect of Myostatin treatment on proteolytic gene expressioCraig McFarlaneAgResearchErin Plummer...
Destruction of Myc by ubiquitin-Mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J. 1999; 18:717–726. 21. Wang S, Jiang W, Chen X, Zhang C, Li H, Hou W, Liu Z, McNutt MA, Lu F, Li G. Alpha-fetoprotein acts as a novel signal molecule and ...
a The enrichment plot of P53 signaling and ubiquitin mediated proteolysis in TCGA and ICGC datasets. b The expression of P53 signaling of HCC cells with PRIM1 knockdown or overexpression. c The expression of P53 expression in PRIM1-overexpressed HepG2 cells treated with boriezomib. d Expression...
Finally, an important positive regulatory function of DUBs is the recycling of ubiquitin from proteins following their commitment to proteolysis by either the proteasome or lysosome/vacuole [10,11]. There are two known classes of DUBs: the ubiquitin C-terminal hydrolases (UCHs) and the ubiquitin-...
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008;13:36–47. Article CAS PubMed PubMed Central Google Scholar Lamorte S, Ferrero S, Aschero S, Monitillo L, Bussolati B, ...
Fig. 3:circNDUFB2physically interacts with IGF2BPs and promotes ubiquitin/proteasome-mediated degradation of IGF2BPs. aInteraction of IGF2BP1, IGF2BP2, and IGF2BP3 withcircNDUFB2. β-ACTIN was used as a negative control.bAnalysis forcircNDUFB2enrichment. RIP assay was performed using the...
Red blood cell-mediated microinjection was used to introduce radioiodinated ubiquitin into ts85 cells, a mouse cell line that contains a thermolabile ubiquitin-activating enzyme (E1). The proportion of ubiquitin present as histone conjugates, high molecular weight conjugates, and free molecules was ...
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell 2003; 12: 1413–1426. Article CAS PubMed Google Scholar Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP . Pin1 regulates turnover and subcellular localization of ...
Ubiquitin Mediated Proteolysis Pathway 466 ncbi summary : Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that ...
Furthermore, activation of both ubiquitin-proteasome and autophagy-lysosome routes may be advantageous, as this would allow effective clearance of both monomeric and oligomeric species, the latter which are inaccessible to the proteasome. Here we find that compounds that activate the D1 ATPase ...