The method for determining functional activity of protein C in a human plasma sample includes incubating the human plasma sample with exogenous reagents that activate factor V and a common pathway of the blood coagulation mechanism through factor X, with activated exogenous protein C and with ...
The decision to test for activated protein C resistance and factor V Leiden mutation should be made on an individual basis. Reasonable guidelines are to test young patients with stroke without other prominent risk factors, those with a family history of thrombotic or venous occlusive disease, patien...
A Rapid Activated Protein C Sensitivity Test as a Diagnostic Marker for a Suspected Venous Thromboembolism in Pregnancy and PuerperiumHiraiK.SugimuraM.OhashiR.SuzukiItohH.SugiharaingentaconnectGynecologic & Obstetric InvestigationHirai+K,+Sugimura+M,+Ohashi+R,+Suzuki+K,+Itoh+H,+Sugihara+K,+et+al.+...
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We hypothesized that recombinant human activated protein C (APC) treatment would improve outcomes in severe sepsis patients who have elevated troponin. Methods Patients with severe sepsis by consensus criteria in auniversity ICU were divided into atroponin elevated group (cTnI + ) and anormal ...
1. A method of determining the sensitivity relative to activated protein C in a test sample, comprising the steps of (a) reacting factor X, activated factor IX, activated protein C and thrombin with the test sample in a test solution containing calcium ions and phospholipids, the test sample...
Using this differential expression data, GO term enrichment was completed to observe possible biological processes impacted by AD progression. Utilizing anti-inflammatory and cyto-protective recombinant Activated Protein C (APC), the researchers uncovered inflammatory processes to be downregulated by APC trea...
C Male,L Mitchell,J Julian,... - 《Blood》 被引量: 132发表: 2001年 Activated protein C resistance determined with a thrombin generation‐based test is associated with thrombotic events in patients with lupus anticoagulants Summary. Background: Several studies suggest that antiphospholipid antibodies...
Some authors described possible acquired activated protein C resistance (APCR) during normal pregnancy. We wanted to test this possibility and to evaluate if this acquired APCR might contribute to the known increased tendency to thrombosis associated with pregnancy. To answer the first hypothesis, we ...
17. A method of screening to identify test substances which modulate the activity of activated protein C on the induction or repression of genes comprising: (i) Contacting a cell with a test substance in combination with activated protein C; (ii) Monitoring expression of a transcript or its tr...