Combination therapy with anti‐cytotoxic T lymphocyte‐associated protein 4 (CTLA‐4) and anti‐programmed death‐1 (PD‐1) monoclonal antibodies (mAbs) has dramatically improved the prognosis of patients with multiple types of cancer, including renal cell carcinoma (RCC). However, more than half ...
Physiologic function of the CTLA-4 receptor CTLA-4B7CostimulationAnergyApoptosisCostimulatory molecules of the B7 family regulate the activation of T lymphocytes. T cell activation is promoted by binding... P Scheipers,H Reiser - 《Immunologic Research》 被引量: 400发表: 1998年 Immune functions of...
CD28, initially detected on human T lymphocytes with the help of antibodies, and CTLA-4, obtained by reverse genetics through its preferential expression in mouse activated T cells, are both single-V domain members of the Ig superfamily. Early work showed a relationship between these two molecules...
Up-regulation of CD152 (CTLA-4) was selective, since it was found to be preferentially expressed on the CD30+ population. Competitive experiments using soluble blocking peptides showed that addition of CD28 or CD80 peptide recovered LPS-induced down-regulation of CD27high expression on CD30+ T...
the rest of the masks show a very small CTLA-4 binding to the tumors, except for other tumour-specific proteins that can be isolated by protein splitting.Therefore, active human CTLA-4 antibody can inhibit tumor activity and reduce the side effects associated with CTLA-4 activity outside the...
CTLA-4 expression and secretion by MSC was confirmed using immunoblot and ELISA, respectively. Co-culture of MSC with PHA-activated PBMC significantly reduced the amount of secreted TNF伪 (p<0,05) which could be reversed by anti-CTLA-4-antibody (p<0,05), under both normoxic and compared ...
Decreased CD28 signaling and activated CTLA-4 pathways during acute thymic atrophy.Matthew J. BillardAmanda L. GruverGregory D. Sempowski
CTLA-4receptorCD95 AntigensApoptosisCD95抗原脱噬作用The fusion protein CTLA-4 . FasL, a paradigmatic "trans signal converter protein", can attach to APC surfaces and in effect convert B7-activating costimulator signals into inhibitory Fas receptor-generated signals. The present study investigates ...
Introduction The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb therapy. To overcome these limitations, we have developed XTX...
(1998) Fas-independent death of activated CD4 T lymphocytes induced by CTLA-4 crosslinking. Proceedings of the National Academy of Sciences of the United States of America, 95, 10083±10088.Scheipers P,Reiser H.Fas-independent death of activated CD4+T lymphocyte induced by CTLA-4 crossing...