activatable probesNIR-II imagingfluorescenceOrganic-dye based NIR-II fluorescent probes, owing to their high signal-to-background ratio and deeper penetration, are highly useful for deep-tissue high-contrast imaging in vivo. However, due to the lack of suitable dyes, it is still a challenge to...
Fluorescent probes in the second near‐infrared window (NIR‐II) allow high‐resolution bioimaging with deep‐tissue penetration. However, existing NIR‐II materials often have poor signal‐to‐background ratios because of the lack of target specificity. Herein, an activatable NIR‐II nanoprobe for ...
While second near-infrared (NIR-II) fluorescence imaging is a promising tool for real-time surveillance of surgical operations, the previously reported organic NIR-II luminescent materials for in vivo imaging are predominantly activated by expensive lasers or X-ray with high power and poor illuminatio...
(A) Synthesis, Structure, and Maximal Emissionavelength of the NIR-II Fluorescent Probesa and(B)esponse Mechanism of WD-X to Viscosity is to say, the lower the orbital energy gap is, the longer the absorption/emission wavelengths are.Except for WD-NME2,the other three molecules are ...
& Shi, C. A review of NIR dyes in cancer targeting and imaging. Biomaterials. 32, 7127–38 (2011). Article CAS PubMed Google Scholar Shimizu, Y. et al. In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe. Cancer. Sci. ...
Pdot-based NIR fluorescent probes provide remarkable advantages over conventional small fluorophores since most NIR fluorescent dyes are subjected to poor solubility in aqueous solutions, fast photobleaching, low fluorescence brightness, and small Stokes shift [10]. In addition, multiple types of ...
Free Trastuzumab conjugated to a NIR fluorescent dye (Tras-DY) could only be internalized by the HER2-expressing cells (Fig. 4C). This substantiates the selectivity of Trastuzumab for HER2 expressing cells and underlines the feasibility of the bispecific liposomes to detect both FAP and HER2 ...
Considering the penetration depth limitation of NIR-I and the limited H2O2 concentration in TME, NIR-II PTT and H2O2 enriched vector should be devel- oped in the future. Experimental section Materials and reagents Iron tri(acetylacetonate), oleic acid, and benzyl ether were purchased from Sigma...
fluorescent 2′,7′-dichlorodihydrofluorescein (DCF) in the presence of1O234. As shown in Fig.3g, h, obvious green fluorescence signals of DCF were detected in SPNpro-, SPN-1-, or SPN-2-incubated 4T1 cells only after NIR photoirradiation, which were 83.3-, 79.4-, and 71.6-fold ...
(9A) The structure of NQO1 activatable NIR fluorescent probe NIR-ASM. (9B) NIR-ASM activation and accumulation in NQO1 expressing cancer cells. (9C) Synthesis of NIR-ASM by coupling ASM with quinone propionic acid (QPA) in the presence of EDCI. (9D) absorbance and (9E) fluorescence ...