Resting potential, the imbalance of electrical charge that exists between the interior of electrically excitable neurons and their surroundings. The resting potential of electrically excitable cells lies in the range of −60 to −95 millivolts. Learn
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As a result, the action potential amplitude in tissue is generally reduced compared to the amplitude in single cells (or in tissue regions where a stimulating current is injected directly). Fig. 7 shows decreased action potential amplitude in tissue compared to single cells for five differen...
In subject area: Biochemistry, Genetics and Molecular Biology The cardiac action potential is a measurement of the membrane potential waveform of the cardiac myocytes signifying the electrical activity of the cell during the contraction and relaxation of the heart. ...
Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions Small molecule stabilizers of protein–protein interactions hold great therapeutic potential. Based on virtual screening and molecular docking, the authors here develop a strategy to evolve weak,...
Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal therapeutic modes of action at the molecular level. Here we describe a system, called BEHAV3D, develope
Big data also has many potential benefits for translational research into health and well-being. Integrated data sets should improve models of common disease to better understand the progression of rare diseases [32]. They may also enable the detection of population-level effects, such as the off...
If the inside of a cell becomes electronegative (i.e., if the potential difference or the voltage reaches a level higher than that of the resting potential), then the membrane or the cell becomes hyperpolarized. However, when the inside of the cell becomes less negative (i.e., the potenti...
M. Nanoelectronics-biology frontier: from nanoscopic probes for action potential recording in live cells to three- dimensional cyborg tissues. Nano Today 8, 351-373 (2013).Duan, X., Fub, T.-M., Liub, J. & Lieber, C. M. Nanoelectronics-biology frontier: From nanoscopic probes for action...
Such work suggests that rationality and irrationality are best conceived as a broad continuum (Lerner et al., 2018a), with actual human thought and action lying somewhere in between. In a sign of potential cracks in EAT's wall of rationality, even Zellweger and Zenger (2021) point to ...