In subject area:Biochemistry, Genetics and Molecular Biology The cardiac action potential is a measurement of the membrane potential waveform of the cardiac myocytes signifying the electrical activity of the cell during the contraction and relaxation of the heart. ...
There are 100 billion neurons in the human brain, and there are a quadrillion synapses in the human brain. Any neuron will have on average of 1000 synapses which influence the electrical potential of the membrane. When the resting membrane potential (-60mV) becomes less negative, it depolarize...
Synaptic vesicles fuse with the presynaptic membrane upon the arrival of an action potential at the presynaptic axon terminal. 突触前轴突末端动作电位到来之际,突触泡同突触前膜相融合。 权威例句 A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentrat...
摘要: Fresh ideas suggested by the first numerical reconstruction of the action potential in a mammalian neuron are 1) role of the A-current and the starting membrane potential level, 2) fast kinetics of the pericellular K+ accumulation, and 3) spike-related Ca2+ movements....
In this paper, a ghost structure (GS) method is proposed to simulate the monodomain model in irregular computational domains using finite difference without regenerating body-fitted grids. In order to verify the validity of the GS method, it is first use
To this end, we herein present a multiphysics setup combining nanoindentation and patch clamp systems, assembled in an inverted microscope for simultaneous bright-field or fluorescence imaging. We evaluate the potential of the platform with a set of experiments in which single dorsal root ganglion-...
Conservation planning under climate change: accounting for adaptive potential and migration capacity in species distribution models AimA number of assumptions underpinning the use of species distribution models to predict biological responses to climate change are violated for temperate... A Hamann,SN Aitken...
News & Views29 Jul 2024 Nature Chemical Biology P: 1-2 F-boxing substrates away A major bottleneck of targeted protein degradation (TPD) has been the discovery of E3 ligases that are amenable to this strategy. Two new studies highlight the potential of FBXO22 as a candidate for TPD, ...
Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in hemolysis, which reduces nitric oxide (NO) bioavailabil...
The location of the testing center plays a significant role, particularly in terms of accessibility and convenience. Opting for a center that is easily reachable from your home or workplace can simplify the testing process, reducing travel time and potential exposure to crowded spaces. COVID-19 ...