Male Long-Evans rats (Charles-River Laboratories, Raleigh, NC, USA.) were used for all experiments except BSR testing for which male DAT-Cre mice were used. Upon arrival, animals were group-housed in an animal facility under a reversed 12 h light-dark cycle (light on at 7:00 PM) wi...
decreases mortality risk and increases longevity. However, the mechanisms involved are poorly understood. The modulating effect of physical (aerobic and resistance) exercise on gene expression has been known for some time now and has