Assessment of the analgesic action of opioid agonist-antagonists in the rabbitAdverse effectsAnalgesicsButorphanolThe analgesic actions of buprenorphine, butorphanol, nalbuphine and pentazocine were assessed in the rabbit by analgesiometry using a thermal stimulus. All four compounds produced effective ...
Martin [2] concluded that the analgesic action of nalorphine is mediated by a receptor, later called the k-opioid receptor, that is different from the morphine receptor. Evidence for multiple receptors, m, k and s, came from the demonstration of different profiles of pharmacological activity ...
Analgesics of a therapeutically effective amount and I described a method for the treatment of patients undergoing analgesic therapy comprising alone devazepide doses to save analgesics, simultaneous or sequential administration. Furthermore, I also described the use of devazepide in the production of...
The patients were veterans with chronic painful conditions who began therapy with opioid analgesics between January 1, 2000, and December 31, 2009. Main Outcomes and Measures Unintentional overdoses that are explicitly coded using International Classification of Disease, Ninth Revision codes as drug or...
By avoiding side effects associated with μ-opioid analgesics, this drug combination might become an important new pharmacological therapy for pain relief.Previous article in issue Next article in issue Keywords κ-opioid hyperalgesia males females pain gender...
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a
Various therapeutic methods, such as non-pharmacological approaches (acupuncture and electric stimulation) and drugs (opioid analgesics, anti-convulsants, gabapentin, tricyclic anti- depressants and local anesthetics), have been used to treat NP[5]. However, the treatment effectiveness has not been ...
In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics Evidence has been adduced for the view that the morphiness receptor or receptors in the myenteric plexus of guinea pig ileum are very similar to the brain receptors that mediate the analgesic action of the narc...
The special scientific analysis was carried out in 274 patients who got different analgesics with peripheral action (aspisol, baralgin, ketoprofen, ketorolak, contrikal) at different stages of preoperative period in combination with opioid. The control group included 30 patients who got monoanalgesia...
Synthetic opioids, like remifentanil, are drugs created in a laboratory with the same analgesic (pain-relieving) effects as natural opioids. The first synthetic opioid, fentanyl, was created in 1960 as part of a search for a potent, rapid-acting painkiller....