Communication between neurons relies on chemical synapses and the release of neurotransmitters into the synaptic cleft. Neurotransmitter release is an exquisitely regulated membrane fusion event that requires the linking of an electrical nerve stimulus to Ca2+ influx, which leads to the fusion of ...
Thus, the kinetics of tubocurarine inhibition depend on the density of ACh receptors in the synaptic cleft. 6. After treatment with collagenase, part of the nerve terminal is displaced and the post-synaptic membrane is exposed directly to the external solution. Under these circumstances, 1/tau ...
Via this action, SSRIs are able to increase the level of neurotransmitter serotonin in the synaptic cleft available to binding to the postsynaptic receptors. This approach to increasing the effectiveness of a neurotransmitter (monoamine) has been thought to be the mechanism of action of most of ...
A variety of actin-binding proteins influence the structure and organization of the actin cytoskeleton. By engaging actin regulatory proteins, synaptic activity can remodel both the pre- and the postsynaptic actin cytoskeleton. In the presynaptic terminal, actin is involved in maintaining and regulating...
This phenomenon is caused by an excess of L-glutamate, or some analogue, in the synaptic cleft. This is due to the inability of astrocytes to recapture it, which in turn gives rise to the overactivation of iGluRs and mGluRs, resulting in neurotoxicity [5,7]. In addition to the ...
This leads to an influx of calcium, which changes the state of certain membrane proteins in the presynaptic membrane, and results with exocitosis of the neurotransmitter in the synaptic cleft. The postsynaptic membrane contains receptors for the neurotransmitters. Once the neurotransmitter binds to ...
配体(ligands) 内源性配体(endogenous ligands) 神经递质(neurotransmitters ) 激素(hormones) 自体活性物质( autocoid) 外源性配体(exogenous ligands): drug Neurotransmitters are chemicals that are released from nerve terminals, diffuse across the synaptic cleft, and bind to pre-or postsynaptic receptors. ...
Receptors have been demonstrated on the terminations of the sympathetic adrenergic nerves. One type, the so-called alpha 2-receptors, are activated by the norepinephrine that is released from the nerve terminals into the synaptic cleft; this activation causes a reduction in the output of the transm...
Action potentials are all-or-none responses generated by receptors at nerve endings that travel along the neuronal axon until it reaches the terminal, where the synaptic cleft exists. Action potentials are fluctuations in cations between the...
At the presynaptic terminal, the arrival of an action potential causes ionic changes (including an influx of calcium) that lead to the release of a chemical neurotransmitter into the synaptic cleft. The neurotransmitter molecules diffuse across the synapse to bind to receptor proteins at the ...