synaptic vesicleSNAREsynaptotagmincomplexinCommunication between neurons relies on chemical synapses and the release of neurotransmitters into the synaptic cleft. Neurotransmitter release is an exquisitely regulated membrane fusion event that requires the linking of an electrical nerve stimulus to Ca2+ influx, ...
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes. Proc. Natl Acad. Sci. USA 102, 19192–19197 (2005). CAS PubMed PubMed Central Google Scholar Rostaing, P. et al. Analysis of synaptic ultrastructure without fixative using high-pressure ...
Once the terminal button is depolarized, it releases a neurotransmitter into the synaptic cleft. The neurotransmitter binds to its receptors on the postsynaptic membrane of the target cell, causing its response either in terms of stimulation or inhibition. Action potentials are propagated faster through...
配体(ligands) 内源性配体(endogenous ligands) 神经递质(neurotransmitters ) 激素(hormones) 自体活性物质( autocoid) 外源性配体(exogenous ligands): drug Neurotransmitters are chemicals that are released from nerve terminals, diffuse across the synaptic cleft, and bind to pre-or postsynaptic receptors. ...
A portion of the presynaptic membrane that faces the postsynaptic density across the synaptic cleft. It constitutes the site of synaptic vesicle clustering, docking and neurotransmitter release. Heteroreceptors Presynaptic receptors that are activated by neurotransmitters released from nerve terminals other th...
Action potentials are all-or-none responses generated by receptors at nerve endings that travel along the neuronal axon until it reaches the terminal, where the synaptic cleft exists. Action potentials are fluctuations in cations between t...
At the presynaptic terminal, the arrival of an action potential causes ionic changes (including an influx of calcium) that lead to the release of a chemical neurotransmitter into the synaptic cleft. The neurotransmitter molecules diffuse across the synapse to bind to receptor proteins at the ...
Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By...
Acetylcholine (ACh), the cholinergic neurotransmitter in the brain is removed from synaptic cleft in the nervous system by the action of acetylcholinesterase (AChE), which splits ACh into choline and acetate [17]. Chang et al., observed that nicotine administration may reduce AChE activities in ...
In retinal ganglion cells, mediates outward currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (By similarity). In adrenal gland, contributes to the maintenance of ...