polymerisation/ Monte Carlo simulationactin filament based cell motilityactin polymerizationtwo-dimensional square latticetreadmillingactin filamentslamellipodia formationCell motility resulting from actin polymerization is modeled on atwo-dimensional square lattice. The treadmilling of actin filaments,formation of ...
Related to actin filament:Intermediate filament,myosin filament ac·tin (ăk′tĭn) n. A protein that forms the microfilaments of the eukaryotic cytoskeleton and plays an important role in cell movement, shape, and internal organization. In muscle cells, it functions with myosin to produce cont...
e, Polar plot showing the distribution of velocity vectors detected in the nuclear region based on actin signal. e′, Directional velocity vectors as shown in e divided into four categories based on their orientation in respect to the nuclear centre (0°). Each category encompasses 120°. f,...
147 A large number of actin-binding proteins have been identified which regulate actin filament assembly and function in cells, and Table 3.2 highlights those which have been identified in platelets. There are six genes encoding different isoforms of the actin monomer protein (3 α-, 1 β-, ...
The relative length changes of actin were measured directly in the latter experiments, but the force acting on a single filament had to be estimated based on estimates of the numbers of actin filament bearing the tension. The values for the forces are therefore possibly less accurate than in ...
The filament elongation rate is set to 10.3 nm/s such that at 600 s, the final length of actin filaments is the cross-section circumference of the droplet, 2π μm (final actin concentration is 27.67 μM). The simulation time of 600 s was chosen based on experimental ...
The filaments are double helical polymers of globular subunits all arranged head-to-tail to give the filament a molecular polarity (Figure 2). Based on the arrowhead pattern created by decoration with myosin, one end is called the barbed end and the other the pointed end. This polarity is ...
Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled the detection of surprising nuclear structures responding to various stimuli, challenging previous models that actin is substantially monomeric in the nucleus. We review these discoveries, focusing on double-stran...
Here we have studied the phosphorylation-dependent effects of PIM1 on actin capping proteins, which bind as heterodimers to the fast-growing actin filament ends and stabilize them. Methods Based on a phosphoproteomics screen for novel PIM substrates, we have used kinase assays and fluorescence-based...
Shows that loss of CP in migrating cultured cells leads to loss of ARP2/3-based lamellipodia and increased numbers of filopodia. Article CAS PubMed Google Scholar Isenberg, G., Aebi, U. & Pollard, T. D. An actin-binding protein from Acanthamoeba regulates actin filament polymerization and ...