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Human formic acid inactivated and paraffin embedded tissues were cut into 2 μm sections. These were dewaxed and antigen retrieval was performed for 30 min at 96 °C in 10 mM citrate buffer pH 6.0. Mouse tissues were likewise inactivated in 98% formic acid, washed, incubated in ...
(Fig.1b). In contrast, expression of either αSyn WT or A53T had no effect on the mitochondrial matrix protease LonP or the ClpP ATP-binding subunit ClpX-like (ClpX, an essential component of ClpXP protease complex [44]) in the above cell cultures (Fig.1a, b). The level of ClpP ...
and there were no instances where inclusions were initially visualized in the cell body and then later progressed into the axon (Fig.5b). We believe that in ~ 20% of cells, where the first imaging session demonstrated axon and cell body inclusions simultaneously, we are seeing a time point...
(Carl Roth, Cat #0335.3, PFA) in 0.1 M phosphate buffer, pH 7.4. Brains were dissected, post-fixed in 4% PFA for 3 h, transferred to phosphate-buffered saline and embedded in paraffin. 5µm thick serial sections were deparaffinized with xylene and dehydrated through a graded ethanol ...
degrades proteins, a-syn oligomers can cause proteasomal dysfunction, which in turn results in the accumulation of a-syn oligomers.Inflammatory responsemicroglial cells respond to a-syn oligomers and produce neuro-inflammatory signals.Membrane damageoligomers can interact with the plasma membrane ...
(Carl Roth, Cat #0335.3, PFA) in 0.1 M phosphate buffer, pH 7.4. Brains were dissected, post-fixed in 4% PFA for 3 h, transferred to phosphate-buffered saline and embedded in paraffin. 5µm thick serial sections were deparaffinized with xylene and dehydrated through a graded ethanol ...
(dpi) and involved hind-limb clasping, ataxia and loss of weight. Mice were scored and euthanized when they showed consistent progression of the diseases (developed kyphosis, became lethargic or could no longer ambulate) at 176–238 days post-inoculation. Upon euthanasia, brains were dissected ...