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Alpha actinins (ACTNs) are known for their ability to modulate cytoskeletal organization and cell motility by cross-linking actin filaments. We show here that ACTN4 harbors a functional LXXLL receptor interaction motif, interacts with nuclear receptors in vitro and in mammalian cells, and potently ...
Acknowledgments We thank Dr. K. Mogami for help in the initial phase of this work, Dr. A. Nagasaki for technical assistance with the RT-PCR, and Dr. S. Iwai for comments on the manuscript.REFERENCES 1 T.D. Pollard, L. Blanchoin, R.D. Mullins Annu. Rev. Biophys. Biomol. Struct.,...
We also would like to thank Dr. Vishnu Baba Sundaresan from the Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, for assisting with the Near Field Electrophysiology experiments. Prof. Seena Ajit (Drexel University College of Medicine), and Prof. Raj ...
Understanding the structural organization of organs and organisms at the cellular level is a fundamental challenge in biology. This task has been approached by reconstructing three-dimensional structure from images taken from serially sectioned tissues,
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Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that Act1 functions as
“I believe Dr. Héroux has presented a compelling case that non-ionizing radiation can impact the path of these charged particles and affect not only the efficiency of energy production in the cell but also increase the production of reactive oxygen species, which can lead to cellular oxidative...
Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy. Protein S-palmitoylation, a powerful post-translational lipid modification, is wel