Our results presented here, suggest that Gem and Brm may normally play a role in balancing EGFR–Ras–MAPK signaling activity during development, thereby affecting cell proliferation or differentiation. In mammals, there is extensive evidence that the Ras–MAPK pathway is activated in tumorigenesis, ...
Nevertheless, whether these changes play a relevant role in TK/GCV mechanism of action or are mere side events remains to be clarified. In this study we have analyzed, by using a first generation adenoviral vector to express TK under a CMV promoter, the response to TK/GCV treatment of a ...