2024年11月18日,浙江大学转化医学研究院、浙江大学医学院附属第一医院、国家基础科学中心及浙江大学基础交叉研究院吕志民教授团队与Rice University陶一之团队合作,在Cell Metabolism(IF=27.7)期刊上发表了题为“ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to fu
Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to the expression of Wnt/尾-catenin, NF-魏B, and PD-L1 and brain tumor growth and immune evasion. A combination treatment with an ACSS2-KAT2A interaction-blocking peptide and an anti-PD-1 antibody induces an ...
Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to the expression of Wnt/β-catenin, NF-κB, and PD-L1 and brain tumor growth and immune evasion. A combination treatment with an ACSS2-KAT2A interaction-blocking peptide and an anti-PD-1 antibody induces an ...
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion Cell Metabolism Volume 37, Issue 2, 4 February 2025, Pages 361-376.e7 Purchase options CorporateFor R&D professionals working in corporate organizations. Aca...
However, an apparent decrease in mRNA level of Acss2 (P = 0.046) and a consistent decrease in ACSS2 protein expression (P = 0.033) (Fig. S1A and B) were evident at 8 months of age, with no similar trends detected at 2 or 5 months old. As ACSS2 acts as a key...
Polyamines are polycations that exhibit high binding affinities towards nucleic acids and ensure optimal control over cellular processes such as DNA replication, transcription, translation and cell-cycle progression47,48,49. The polyamine metabolite N1-acetylspermidine acts as a substrate for histone modific...
背景资料This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation.The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP.Expression of this gene is regulated by sterol regulatory element...
背景资料Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation.The protein acts as a monomer and produces acet...
4,5 Like other small GTPases, KRAS acts as a binary molecular switch between an active GTP-bound state and an inactive GDP-bound state. Guanine nucleotide exchange factors (GEFs), such as SOS, RASGRF, and RasGRP, assist in the exchange of GDP with GTP.6,7,8 GTPase activating proteins...