2024年11月18日,浙江大学转化医学研究院、浙江大学医学院附属第一医院、国家基础科学中心及浙江大学基础交叉研究院吕志民教授团队与Rice University陶一之团队合作,在Cell Metabolism(IF=27.7)期刊上发表了题为“ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histo...
2024年11月18日,浙江大学转化医学研究院、浙江大学医学院附属第一医院、国家基础科学中心及浙江大学基础交叉研究院吕志民教授团队与Rice University陶一之团队合作,在Cell Metabolism(IF=27.7)期刊上发表了题为“ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histo...
Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to the expression of Wnt/β-catenin, NF-κB, and PD-L1 and brain tumor growth and immune evasion. A combination treatment with an ACSS2-KAT2A interaction-blocking peptide and an anti-PD-1 antibody induces an ...
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion Cell Metabolism Available online 18 November 2024 Purchase options CorporateFor R&D professionals working in corporate organizations. ...
ACSS2 Antibody is a Rabbit Polyclonal antibody against ACSS2. This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expres...
背景资料 Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation.The protein acts as a monomer and produces ac...
Polyamines are polycations that exhibit high binding affinities towards nucleic acids and ensure optimal control over cellular processes such as DNA replication, transcription, translation and cell-cycle progression47,48,49. The polyamine metabolite N1-acetylspermidine acts as a substrate for histone modific...