This amazing and beloved market is one of Melbourne’s landmarks and one of the largest open-air markets in the world (17 acres). It features day and night markets with a vast array of stalls ranging from designer and vintage clothing, Australian made wares and arts and crafts, to food ...
Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative
distribution of various conformations during parallel folding events15. In this “funnel” theory, the so-called off-pathway states are energy traps that are direct and “on-route” for the population involved in these pathways. In more recent years, different hierarchical hypotheses have been reviv...
To date, ibrutinib is the only BTK inhibitor that has received marketing authorization for the treatment of B cell malignancies (Ponader and Burger, 2014); however, it is associated with adverse events not likely due to inhibition of BTK function, based on clinical observations in patients with...