在强声音刺激之前的一定时间(几十至几百毫秒)内,先出现一个弱的阂下声音刺激(即前脉冲),会降低动物对强声音刺激的听震惊反射幅度((startle amplitude, SA),对震惊反射幅度的抑制率即为PPI。对于啮齿类动物,震惊反射幅度和PPI数值可以通过震惊反射系统(startle response system)获得。当感觉运动门控功能正常时,动物具...
Increases in the acoustic startle response (ASR) of animals have been reported following experimental manipulations to induce tinnitus, an auditory disorder defined by phantom perception of sound. The increases in ASR have been proposed to signify the development of hyperacusis, a clinical condition ...
Increases in the acoustic startle response (ASR) of animals have been reported following experimental manipulations to induce tinnitus, an auditory disorder defined by phantom perception of sound. The increases in ASR have been proposed to signify the development of hyperacusis, a clinical condition def...
AIMS: An assessment of the acoustic startle response (ASR) and prepulse inhibition (PPI) of ASR in laboratory animals is used to model human anxiety and psychotic states, respectively. The aim of the study was to evaluate ASR and PPI in alcohol-naive male and female Warsaw alcohol high-prefe...
The acoustic startle response (ASR) depends on stimulus parameters such as duration, intensity and particularly on the stimulus rise time. The aim of our study was to determine to what extent the ASR parameters are affected by the spectral characteristics of the stimulus. Therefore, in this exper...
An assessment of the acoustic startle response (ASR) and prepulse inhibition (PPI) of ASR in laboratory animals is used to model human anxiety and psychotic states, respectively. The aim of the study was to evaluate ASR and PPI in alcohol-naive male and female Warsaw alcohol high-preferring ...
Prepulse inhibition (PPI) of the acoustic startle response (ASR) is used as a measure for sensorimotor gating and it has been reported that PPI is disrupted by memantine. However, the mechanism of memantine-induced PPI disruption remains unclear. In the present study, we investigated the effects...
ASR reactivity modulation after brief stimulation has not been experimentally tested. Table 4. Acoustic startle response in hearing-impaired animals StudiesAnimalsHearing loss inducerMonaural/binauralRecovery timeType of measuresReported effect Chen (1978) BALB/C mice of ±P2140 Acoustic trauma40 Sham ...
The acoustic startle response (ASR) can be enhanced by administration of footshocks (sensitization). The neural mechanisms underlying this effect are largely unknown. A previous electrophysiological study (Kungel et al., Brain Res., 643 (1994) 29-39) has shown that the neuropeptide substance P ...
The acoustic startle response (ASR) can be enhanced by administration of footshocks (sensitization). The neural mechanisms underlying this effect are largely unknown. A previous electrophysiological study (Kungel et al., Brain Res., 643 (1994) 29–39) has shown that the neuropeptide substance P...