Plant-derived grayanotoxins (Ericaceae family), veratridine (Liliaceae family), and acotinine (Aconitum napellus) as well as the frog skin-derived batrachotoxin (Phyllobates aurotaenia) bind to the S6 segments of domains I and IV of Nav channels, also referred to as “neurotoxin site 2.”...
napellus31. Compound 4 was isolated as an amorphous powder and its LR-ESI-MS showed a [M + H+] peak at (m/z): 438 and the HR-EI-MS exhibited a peak at 438.2863 which corresponded to the protonated molecular formula oofusCly24fHro39mNOA6..feTrhoexs2e8. 1H-NMR ...
Two complete series of investigations were performed in order to assess the activity of Gelsemium sempervirens; furthermore, we investigated Ignatia amara and Aconitum napellus in the same model systems.#13; Methods: Mice of CD1 strain were randomized in different cages (minimum 8 mice per treated...