2025 年,2 月 27 日,北京大学未来技术学院肖瑞平和胡新立团队在Cell Metabolism杂志发表了论文MIF-ACKR3 Causes Irreversible Fat Loss by Impairing Adipogenesis in Cancer Cachexia,揭示了巨噬细胞迁移抑制因子(Macrophage migration inhibitory...
Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interfaceChemokinesDecoy receptorsImmune cellsPlacentaEstablishment of immune cell populations and adaptations in immune cells are critical aspects during pregnancy that lead to protection of the semi-allogenic ...
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cell proliferation and migration, tumor...
趋化因子C-X-C-基元受体7(CXCR7)重组蛋白 Recombinant Chemokine C-X-C-Motif Receptor 7 (CXCR7) ACKR3; RDC1; CMKOR1; GPR159; Chemokine Orphan Receptor 1; Atypical chemokine receptor 3; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog来源:原核表达宿主:E.coli...
Recently, we described that platelets express the chemokine receptor ACKR3 (Atypical chemokine receptor 3, formally known as CXCR7 (C-X-C chemokine receptor type 7) or RDC-1)13,14. The binding of ligands such as MIF to ACKR3 attenuates thrombus formation suggesting a role of platelet-ACKR3...
ACKR3 should not be classified as GPCR rather as a seven-transmembrane domain receptor (7TMDR) (Balabanian et al.2005; Burns et al.2006; Kapas and Clark1995; Klein et al.2014). Nevertheless, ACKR3 is a functional cell surface receptor as it shows ligand-induced responses such as enhanced...
c chemokine receptor type 7as a treatment of cardiac fibrosis,j.med.chem,2018,61(8):3685 ‑ 3696中描述的化合物18,其具有11nm的ec 50 。 71.因此,在优选实施方式中,肽包含、基本上由或由氨基酸序列fggx1mrrx2(seq id no:1)组成,其中x1是f并且x2是k。换言之,在优选实施方式中,肽包含,基本上...
* b), protein levels ( ), relative protein densities ( ) of CXCR7 in ihMSCs incubated with control medium or CM collected from indicated condition that was treated with or without neutralizing anti-VEGF antibody (VEGF n.a., 100ng/ml) for 18h. Data are means卤SD ( =9). * # e The...
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or trans
ACKR3; CMKOR1; CXCR7; GPR159; RDC1; Atypical chemokine receptor 3; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1 种属: Homo sapiens (Human) 来源: Mammalian cell 表...