Mechanically, Hh promotes RCC progression through GLI1‐mediated ACKR3 transcription by the directly binding of GLI1 to ACKR3 gene, while CXCL12–ACKR3 axis simultaneously enhances Hh activation via the binding of ACKR3 to Smoothened (SMO), a receptor in Hh pathway, resulting in the up...
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also ...
背景资料Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.This gene encodes a member of the G-protein coupled receptor family.Although this protein was...
技术领域 1.本发明广泛涉及医学领域,并提供可用于包括诊断和治疗的不同领域的新型非典型趋化因子受体3(ackr3)调节分子,其本身以及作为与其他药剂的融合蛋白,并进一步提供所述ackr3调节分子的方法和用途。 背景技术: 2.阿片样物质受体是由中枢神经系统和免疫细胞表达的g蛋白偶联受体(gpcr),在调节镇痛、奖励处理以及压...
[14]Shi J, Zhang P, Liu L, et al. Weighted gene coexpression network analysis identifies a new biomarker of CENPF for prediction disease prognosis and progression in nonmuscle invasive bladder cancer[J]. Mol Genet Genomic Med, 2019...
Rat ACKR3 shRNA Plasmid的详细介绍 shRNA Plasmid to inhibit ACKR3 expression by RNA interference. This product contains 3 separate slightly different shRNA sequences which knock down rat ACKR3 gene specifically. Each vial contains 50 μg of lyophilized shRNA. ...
ACKR7 is a seven-transmembrane domain receptor phylogenetically related to the rhodopsin-like family of G protein-coupled receptors (GPCRs) which binds the chemokines CXCL12/SDF-1 (Kd~ 0.4 nM) and CXCL11/I-TAC (Kd~ 4 nM) and the peptide hormone adrenomedullin (Kd~ 0.2 nM), but appears...
PCR was performed on QX200 Droplet Digital PCR (ddPCR™) system from Bio-Rad. 20µL reaction mixes were prepared using 10μL of 2X ddPCR SuperMix for probes (No dUTP) (Bio-Rad), 1µL of 20X FAM-labeled primer/probe for the target gene, 1µL of 20X VIC-labeled primer/probe...
The Ackr3 gene targeting vectors were constructed from genomic murine C57BL/6 DNA spanning exon 2 and the flanking regions of the Ackr3 gene. In the vector, a HA-tag was inserted in-frame with the ATG in exon 2, in order to produce an HA-ACKR3 fusion protein. For the HA-ACKR3-ST...
a–cRelative gene expression of ACKR3 and classical opioid receptors in smNPCs and different brain regions corresponding to centers important for opioid peptide activity. Box plots encompass 25th to 75th percentile with median as central mark and whiskers extending to most extreme data points.aRNA-Se...