T-cell activation is negatively regulated by C-terminal Src kinase (CSK); however, the exact mechanism remains unknown. Here we show that the conserved oncogenic tyrosine kinase Activated CDC42 kinase 1 (ACK1) is able to phosphorylate CSK at Tyrosine 18 (pY18), which enhances CSK function, ...
Activation of platelet ACKR3 is a critical mechanism to limit organ ischemia in I/R. Targeting platelet ACKR3 may be a promising novel strategy to control thrombosis and organ injury in I/R without enhancing bleeding. Methods This study complies with all relevant ethical regulations and was ...
Results Single-cell transcriptome atlas of human tendon adhesion tissue To determine the cellular composition of tendon adhesion tissue, tissue samples were obtained surgically from 12 patients with flexor tendon tenolysis including three samples of normal peritendinous tissue and three pathologic samples ...
Therefore, through this mechanism, CDC42 might also counteract the ability of ACK to promote EGFR ubiquitination. Although we used aggregate-prone polyglutamine-tagged proteins as a readout to examine autophagic activities in this study, we have not examined the pathological aspects of autophagic ...
have a distinctive ligand-binding mode and activation mechanism, showing a particularly high propensity for arrestin recruitment and ligand internalization35,36. In this study, we show that ACKR3 is abundantly expressed in the same brain regions as the classical opioid receptors and that, besides BAM...