A. baumanniidevelops biofilms three times faster than the other Acinetobacter species at the solid–liquid interface. Clinical strains are more capable of developing biofilms than environmental strains, and the formation of biofilm on surfaces with potential medical importance affects the strains' ability ...
Furthermore, mechanisms of antibiotic resistance of this organism, including acquirement of up-regulation of multidrug efflux pumps and genetic organization are also discussed. Lastly, novel prospective treatment options for infections caused by multi-drug resistantA. baumanniiare summarized as Antimicrobial...
baumannii (ATCC BAA- 1794), with EC50 values between 2 and 3 μg/ml, than against the antibiotic sensitive strains tested, which had EC50 values ranging from 9 to 36 μg/ml. Membrane permeabilization and depolarization by peptides To determine whether Apo5, Apo6, and A1P interacted with ...
A. baumanniiclinical isolates have demonstrated a remarkable ability to successfully battle antibiotic treatment in the clinic due to high intrinsic resistance to antimicrobials and the acquisition of drug resistance elements by the organism10,11,12,13. A critical missing link is a detailed roadmap fo...
Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii Antibiotic resistance is a growing global concern in the field of medicine as it renders bacterial infections difficult to treat and often more severe. Aci... AK Cain,M Hamidian - 《Plos Pathogens》...
baumannii-associated disease can reach up to 68% in specific at-risk patient populations2, there are limited treatment options because of growing antibiotic resistance, and the pharmaceutical pipeline of novel com- pounds targeting this organism remains deficient3–5. The gap in A. baumannii drug ...
Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reduces A. baumannii gr...
carbapenem-resistant Acinetobacter baumannii; BSI, bloodstream infection; –– 0.416 – 0.001 0.040 0.112 – Reference 1.687(0.582–4.889) – 5.707(1.833–17.772) 3.087(1.162–8.198) 3.439(1.032–11.466) –– 0.335 – 0.003 0.024 0.044 The Effect of Definitive Antimicrobial Treatment on the Mortality...
baumannii clinical isolate, the largest antibiotic The clinical impact of Acinetobacter infections Nowadays, Acinetobacter has gained great interest owing to the worldwide emergence of MDR or even pan-resistant strains that either become endemic or suddenly cause outbreaks of infection, usually in ICUs ...
Acinetobacter baumannii: a universal threat to public health? HelenGiamarellou, ...KyriakiKanellakopoulou, inInternational Journal of Antimicrobial Agents, 2008 2Taxonomy Acinetobacterspp. are non-fermentative, strictly aerobic, non-motile, non-pigmented, catalase-positive and oxidase-negative Gram-negativ...