The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of proteins: insights from tail switching and tail removal. J Mol Biol, 304, 135-49.Lee KB & Thomas JO (2000) The effect of the acidic tail on the DNA-binding properties of the HMG1,2 class of ...
Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in the astrocytes which are the most abundant sub
Subtilisin is suggested to remove the α-tubulin and β-tubulin C-terminal regions, which are disordered clusters of acidic amino acid residues (38). Therefore, katanin p60 may recognize the acidic tail of either α-tubulin or β-tubulin or both. To determine which C-terminal tail is ...
effectively blocked by a crystal contact involving the H4 N-terminal tail. This type of interaction has been implicated in chromatin higher order structure17,29,30,31, suggesting that the H4 tail may sterically block compounds from binding to the acidic patch in condensed chromatin states, such ...
In contrast, the conserved mIgG-tail contains many basic and hydrophobic residues with a high pI value of 9.4, suggesting that the mIgG-tail might interact with the negatively charged inner leaflet of the PM. To address this hypothesis, we synthesized a peptide representing the mIgG-tail linked...
Reversible oligonucleosome self-association: dependence on divalent cations and core histone tail domains. Biochemistry 35, 4009–4015 (1996). Article CAS PubMed Google Scholar Shogren-Knaak, M. et al. Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311, ...
deserves careful analysis. The other two features, namely, the folding of the N-terminal tail and its regioselective accumulation of cations, are processes much less analyzed in the literature due to the difficulty of resolving flexible parts of amyloid fibrils. Thus, the present simulations offer ...
Since double phosphorylation within the acidic tail of the protein might contribute to a specific conformation, we compared the Trp fluorescence spectra of the native and dephosphorylated cHMG1 proteins (Fig. 2 A). The emission spectra of the tryptophans of the native and dephosphorylated proteins...
Fig. 2: Conserved basic and acidic regions within a minimal SSX domain are necessary and sufficient for nucleosome binding and BAF complex recruitment and activity. a, Glutathione S-transferase (GST; control) and GST-SSX1 (78 aa) purified recombinant proteins incubated with mammalian mononucleoso...
These compounds are, in general, surface active and are basic in character. A general method of preparing the above reagents comprises heating two molecular equivalents of a fatty acid, or an amount of fatty acid glyceride sufficient to yield the equivalent of 2 mols. of the fatty acid, ...