Thus, suppression of HMGA protein expression has been suggested as a potential way for therapeutic intervention of human malignant neoplasia (Scala et al., 2000). The multi-functionality of HMGA1a is achieved through its high adaptability, due to its intrinsically disordered character (Sgarra et ...
In the case of aromatic alcohols, such as phenol, the peroxide that is formed after the O-H bond cleavage, is stabilized because of the resonance effect of the benzene ring since the electronegative character of the oxygen will be reduced. This will allow the aromatic alcohols to be more a...
With an increasing clinical demand for functional therapeutic proteins every year, there is an increasing requirement for the massive production of bioactive recombinant human acidic fibroblast growth factor (r-haFGF). In this present study, we delicatel
nitric acid and sulfuric acid may also be used, however are less preferred due to their strong acidic character; if present are present in only minor amounts. However, the use of water soluble acids as co-acids are preferred, including water soluble salts of organic acids. When present, the...
I prefer to utilize a sulfonated ether made, for example, by alkylating phenol with di-isobutylene; condensing the product with a dichloropolyalkylene ether such as B-B'dichloroethyl ether to substitute only one of the halogen atoms by the alkylated phenol. This aryloxy polyalkylene ether halide ...
Upon deprotonation in solution, the resulting phenolate oxygen exerts a very strongly electron donating character, leading to an extended π-conjugated push-pull system displaying a bright red emission (Scheme 4, Figure 1 right). It is worthy of mention, that both protonation and deprotonation are...