Reagents and conditions: (a) malonic acid, NH4OAc, EtOH, reflux; (b) PhCH2COCl, Et3N, aq acetone; (c) penicillin amidase, pH 7.5; (d) 6 N HCl (aq); (e) 4 N HCl/1,4-dioxane/MeOH; (f) N-Boc-(R)-nipecotic acid, HBTU, HOBT, NMM, MeCN; (g) 4 N HCl/1,4-dioxane;...
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Compound 40 (Scheme 2) has also been synthesized in excellent yield up to 94–99% by the catalyst [DABCO](SO3H)2(Cl)2 under aqueous and refluxing conditions [119]. Scheme 2. Formation of 5-arylidene barbituric acid derivative. Reagents and conditions: a—[TPPHSP]Br, EtOH-H2O, reflux...