The difference between the acid dissociation constant of this molecule determined in H2O and in D2O implies that a correction of −.25 unit is needed for those p K a values calculated by plotting the chemical shifts in D2O vs the apparent pH meter readings. The p K a found for N α‐...
This is the time taken from the acid dissociation constant. The administration of the anaesthetic to the onset of anaesthesia. The closer the pKa is to local tissue pH (usually 7.4), the more un-ionized the drug is; the higher the pKa, the more ionized it is. Local anaesthetics with a...
How Are pKa and pH Related? pKa (the acid dissociation constant) describes the inherent property of a compound or ionizable functional group to lose H+ and generate hydronium ions (H3O+). pH measures the concentration of hydronium ions (H3O+) in aqueous solution pH = -log [H3O+] Download...
Analyzing cefotaxime again in macro mode, the same aminothiazole presented a negative acid dissociation constant −0.31 while the imine 4.21. In fact, this result indicates that the overlapping ionization of these two groups is likely to create some problems in this program. In this direction, ...
The acid dissociation constant (Ka) is a good indicator of the strength of a given acid, especially for weak acids. The greater the acid dissociation constant, the greater the dissociation of an acid into its constituent ions (i.e., h...
The calculation of dissociation constant (K d) in the interactions between PCA and c-Cyts The Kd was calculated according to the protein-ligand binding model (as shown in Eqs. (1–4)) developed by Okamoto et al.64. $${{{\rm{PCA}}}-c-{{{\rm{Cyts}}}\left({{{\rm{PL}}}\right...
PH: pH of a 0.001% aqueous solution is 3.80, that of 0.1% solution is 2.80, and that of a 1.0% solution is 2.34 Henrys Law Constant: Henry's Law constant = 8.4X10-13 atm-cu m/mol at 25 °C (est) Dissociation Constants: Ionization constants: K1 = 4X10-4; K2 = 9X10-6|...
Henrys Law Constant: Henry's Law constant = 1.26X10-8 atm-cu m/mol at 25 °C (est) Dissociation Constants: pKa = -1.86 Experimental Properties: Not hydrolyzed by boiling water or hot aqueous alkali|Thermally stable at moderately elevated temperatures.|Liquid molar volume = 0.065051 cu ...
Trichloroacetic acid is a strong organic acid with a dissociation constant K = 3 × 10-2. It has lively chemical properties. Its sodium salt is easily subject to decarboxylation into chloroform. It will be reduced to alcohol upon coming across LiAlH4. It can have halogen replacement react...
The first acid dissociation constant (pKa) of this reaction is 5.5 pH; the second pKa has no physiological significance. The solubility constant (Ksp) of uric acid is approximately 100 mg/L in aqueous solutions at 37 °C, while urate is 20 times more soluble. Urate and uric acid exist in...