The invention relates to novel derivatives of acetylsalicylic acid with an NO3 structure. They are therapeutically effective either as intact active agent molecule or after dissociation (NO release). The invention also relates to processes for their production and their use as medicaments, especially ...
The invention relates to new derivatives of acetylsalicylic acid (called ASA in the following), which contain an NO.sub.3 structure. They are therapeutically active either as the intact active compound molecule or after cleavage (NO release). The invention also relates to processes for their prepa...
2.1 Classification of NSAIDs based on structure Based on their chemical structure, NSAIDs can be broadly classified into salicylates, aryl and heteroarylacetic acid derivatives, indole/indene acetic acid derivatives, anthranilates and oxicams (enol acids) (Fig. 1) [27]. The general...
Acetylsalicylic acid AST: Aspartate aminotransferase BALF: Bronchoalveolar fluid CM: Cerebral malaria COX-1: Cyclooxygenase-1 CQ: Chloroquine DAD: Diffuse alveolar damage DHA: Dihydroartemisinin DMSO: Dimethyl sulfoxide Est, L: Lung static elastance KC: Keratinocyte chemoattractant MA-ALI:...
molecule-neutron collisionsneutron diffractionorganic compounds/ acetylsalicylic acidaspirinlibrating methyl groupThe structure of acetylsalicylic acid (2-(acetoyloxy)benzoic acid; Aspirin) has been studied by variable temperature single crystal neutron diffraction. The usual large torsional librational motion ...
Each model structure is subjected to calculation using DFT at B3LYP/6-31G(d,p) model. The reactivity of aspirin is highly affected by several additives, such as NH2, Cl and CN groups. Such behavior constructs a highly sensitive tunable molecule that can be fulfilled in promising applications....
Molecular parameters for protonated complexed aspirin, as found in I, are reported for the first time and reveal a significantly different conformation from that of the uncomplexed aspirin molecule. The structure of the 4-aminosalicylic acid molecule does not change significantly on complexation with ...
The statistics reveal the existence of internal HB that inhibit the rotational movements of the acetyl and the carboxylic acid groups, forcing the molecule to adopt a closed conformer structure in water, and playing an important role in stabilizing this conformation.Maria...
The structures of acetylsalicylic acid (aspirin) (I) and its oxyanion (II) have been studied by means of infrared spectra and ab initio 3-21 G force field calculations. The 3100-1100 cm region bands of both the aspirin molecule and its oxyanion have been assigned. The theoretical infrared ...
(ca. 4.5 g) and each of them was treated with a different activating agent. The aqueous solutions of 85% phosphoric acid (diluted 1:1 v/v (P2) and undiluted (P1)), 95% sulphuric acid (diluted 1:1 v/v (S)), 65% nitric acid (diluted 1:1 v/v (N)), and silver nitrate (9...