W. (1986). Acetylcholinesterase generates enkephalin-like immunoreactivity when it degrades the soluble proteins (chromogranins) from adrenal chromaffin granules. Brain Res. 376, 230-238.Ismael, Z., Millar, T., Small, D. and Chubb. I., Acetylcholin- esterase generates enkephalin-like ...
Acetylcholinesterase (EC 3.1.1.7) has been shown to possess an intrinsic peptidase activity. [Chubb et al. (1983), Neuroscience 10, 1369–1383]. To examine this activity further, the breakdown of a model hexapeptide (leu-trp-met-arg-phe-ala) LWMRFA was studied. Affinity-purified eel acetyl...
Biomimetic single Al-OH site with high acetylcholinesterase-like activity and self-defense ability for neuroprotectionACETYLCHOLINESTERASELEWIS aciditySELF-defenseNERVOUS system injuriesLEWIS acidsMETAL-organic frameworksENZYME kineticsNeurotoxicity of organophosphate compounds (OPs) can catastrophically cause nervous ...
Calderon FH,Bernhard R,et al.Toxic effects of acetylcholinesterase on neuronal and glial -like cells in vitro. Molecular Psychiatry . 1998Calderon,FH,von,Bernhardi,R,De,Ferrari,G,Luza,S,Aldunate,R,Inestrosa,NC.Toxic effects of acetylcholinesterase on neuronal and Glial-like cells in vitro. ...
A single amino acid change in the acetylcholinesterase-like domain of thyro- globulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Proc. Natl. Acad. Sci. USA 95: 9909-9913....
A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Proc Natl Acad Sci USA. 1998; 95(17): 9909-13. [PubMed: 9707574]...
Gomez S, Davious P, Faivre-Bauman A, Valade D, Jeannin C, Rondot P, Puymirat J (1986) Acetylcholinesterase activity and somatostatin-like immunoreactivity in lumbar eerebrospinal fluid of demented patients. In: Fisher A (ed) Alzheimer and Parkinson's diseases. Plenum Press, New York, pp ...
Small DH.Serum acetylcholinesterase possessestrypsin-like and carboxypeptidase B-like activity. Neuroscience Letters . 1988Small DH. Serum acetylcholinesterase possesses trypsin-like and carboxypeptidase B-like activity[J].Neuroscience Letters,1988,(03):307-312.doi:10.1016/0304-3940(88)90676-3....
Acetylcholinesterase (AChE) is the principle degradative enzyme of ACh in the brain and limits the concentrations of ACh in the neuronal synapse. Furthermore, chronic administration of the antidepressant fluoxetine resulted in reduced anxiety- and depression-like behavior in mice. Therefore, we ...
All three compounds exhibited reversible, mixed inhibition of acetylcholinesterase. Importantly, the in silico physicochemical filter facilitated the discovery of CNS drug-like compounds, such that all three inhibitors displayed high in vitro blood-brain barrier model permeability....