There was little evidence that ACh altered the function of central neurons by a direct interaction with an ACh receptor.doi:10.1007/978-94-009-5928-6_3Gregory J. WastekHenry I. YamamuraSpringer NetherlandsGreen DP, Miledi R, Perez de la Mora M, Vincent A. Acetylcholine receptors. Philos ...
The 43 kDa AChR-associated protein rapsyn is required for the clustering of nicotinic acetylcholine receptors (AChRs) at the developing neuromuscular junction, but the functions of other postsynaptic proteins colocalized with the AChR are less clear. Here we use a fibroblast expression system to inve...
尾-Amyloid peptide blocks the response of 伪7-containing nicotinic receptors on hippocampal neurons Alzheimer's disease produces a devastating decline in mental function, with profound effects on learning and memory. Early consequences of the disease incl... Q Liu 被引量: 518发表: 2001年 加载更多...
Neuronal nicotinic acetylcholine receptors (nAChR) are made from different combinations of subunits encoded by a diverse family of genes. However, the recently cloned α7 gene codes for subunits that can form homooligomeric nAChR complexes when expressed in Xenopus oocytes. Electrophysiological studies re...
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance;...
Jon Lindstrom,Rene Anand,Vladimir Gerzanich,Xiao Peng,Fan Wang,Gregg Wells. Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors[J]. Progress in Brain Research . 1996Chapter 10 Structure and function of neuronal nicotinic acetylcholine receptors[J] . Jon Lindstrom,Rene...
Vesicle structure and acetylcholine receptor function. Functionally intact acetylcholine receptors can be solubilized from electric organ membranes of Torpedo californica and incorporated into liposomes by the ... R Anholt,DR Fredkin,T Deerinck,... - 《Journal of Biological Chemistry》 被引量: 109...
nAChR α6 subunit message is abundant in the VTA, but α6*-nAChR cellular localization, function, pharmacology, and roles in cholinergic modulation of dopaminergic (DA) neurons within the VTA are not well understood. Here, we report evidence for α6β2*-nAChR expression on GABA neuronal ...
eye-drops to constrict the pupil during cataract surgery; this occurs because the constrictor pupillae and ciliary muscles of the eyes are both controlled by cranial nerve III, which has a parasympathetic function and can thus activate the M3 receptors of these muscles by acetylcholine secretion.[...
Nicotinic acetylcholine receptors (nAChRs) are best known to function as ligand-gated ion channels in the nervous system. However, recent evidence suggests that nicotine modulates inflammation by desensitizing non-neuronal nAChRs, rather than by inducing channel opening. Silent agonists are molecules that...