N-Acetyl and N-carbamoyl derivatives of the indicated 9-aminoazafluorenes were obtained. According to the PMR spectral data, 3-methyl-2-azafluorenone oxime is produced in the form of a mixture of Z and E isomers. Ketazines corresponding to 3-methyl-2-azafluorenone and 4-azafluorenone ...
N-2-acetylaminofluorene has been shown efficiently to induce both 1 and 2 frameshift mutations in Escherichia coli as well as in mammalian cells. In E. coli , the genetic characteristics of 1 and 2 frameshift mutations were found to be distinct. The 1 frameshift mutation pathway occurs at mo...
The addition of 1,8-pyrenequinone into the assay system containing rat liver homogenates (S-9) caused an approximately 10-fold increase in the mutagenicity of 2-acetylaminofluorene (AAF) in the current Salmonella reversion assay system. Since no chemical reaction between 1,8-pyrenequinone and ...
This indicated that a higher amount of unmetabolized AAF remained and higher amounts of 2-aminofluorene and N-hydroxy-2-acetylaminofluorene were accumulated in the presence of 1,8-pyrenequinone compared with those in the absence of 1,8-pyrenequinone. From these results, it seems probable that...
Beard P, Kaneko M, Cerutti P (1981) N-Acetoxy-acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome. Nature 291: 84–85Beard P, Kaneko M, Carutti P (1981) N-Acetoxyacetylaminofluorene reacts preferentially with a control region of intracellular SV40 ...
Adduct formation be- tween the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxyribonucleotides. Chern Bioi Interact 1977; 17:203-210.Harvan, DJ, Hass, JR, Lieberman, MW (1977) Adduct formation between the carcinogen N-acetoxy-2-acetylaminofluorene and synthetic polydeoxy...
S-phase block and cell death in human lymphoblasts exposed to benzo[a]pyrene diol epoxide or N-acetoxy-2-acetylaminofluorene. Toxicol Appl Pharmacol. 1989; 97 :463–472.Black, K.A. , McFarland, R.D. , Grisham, J.W. , and Smith, G.J. ( 1989b ) S phase block and cell death ...
N-acetoxy- acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome. Nature (Lon- don) 291:84-85.Beard P, Kaneko M, Carutti P (1981) N-Acetoxyacetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome. Nature 291:84–...
J. (1997): Potential effect of sodium nitrite on the expression of nuclear proto- oncogenes during 2-acetyl aminofluorene induced hepatocarcinogenesis in rats. Chem. Biol. Interact. Dec l2; 108(l-2):l-18.Hsu JD,,Hsu CL,Chou FP,et al.Potential effect of so-diumnitrite on the expression...
Light reversal of carbon monoxide inhibition of 2-acetylaminofluorene (AAF) N- and ringhydroxylations is examined with liver microsomes from 3-methylcholanthrene (MC) pretreated hamsters. Photochemical action spectra indicate that carbon monoxide inhibition of ring-hydroxylation is readily reversed by ...